Paracetamol increases the incidence of neutropenia, because this substance suppresses the metabolism of zidovudine (both drugs undergo glucuronization).
Inhibitors of oxidative processes of microsomes inside the liver (among them morphine with oxazepam, codeine, ASA and clofibrate, and in addition indomethacin with cimetidine) increase the plasma values of zidovudine.
Drugs with nephrotoxic properties, as well as depressing bone marrow function (such as amphotericin, vinblastine with ganciclovir and pentamidine, and additionally vincristine), increase the likelihood of developing a toxic effect in zidovudine.
Drugs that slow the secretion of the tubules, prolong the half-life of zidovudine.
Zidovudine increases the fluconazole index in the body.
When combined with other medicines against the HIV virus (especially lamivudine), a synergistic effect occurs with respect to replication of HIV infection in the cell culture.
Ribavirin inhibits the process of zidovudine phosphorylation before the formation of triphosphate, so these drugs can not be used in combination.
Stavudine has antagonistic properties when the molar values of this substance with zidovudine have a proportion of 20k1. As a consequence, the combination with stavudine is prohibited.