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Alendros 70
Last reviewed: 23.04.2024
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Alendros 70 - a drug that alters the processes of mineralization and bone structure. Contains bisphosphonates.
Alendronate Na slows down bone resorption involving osteoclasts, while not having a direct effect on the process of bone formation. In preclinical tests, the predominant localization of the substance was found in areas with active resorption processes. The drug slows down the activity of osteoclasts, without affecting the synthesis and accumulation of osteoclasts. The bones formed by using alendronate are of fairly high quality.
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Indications Alendros 70
It is used in women in the case of osteoporosis associated with postmenopausal women.
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Release form
The release of the drug is carried out in tablets - 2 pieces inside the cellular packaging. In the box 1, 2, 4 or 6 such packages.
Pharmacokinetics
When ingested, the level of bioavailability of alendronate was 0.64% at dosages of 5-70 mg taken on an empty stomach 2 hours before breakfast. The bioavailability indices decreased according to this scheme to approximately 0.46%, as well as 0.39% with the administration of the drug 1 hour or half an hour before breakfast. When testing osteoporosis, the drug showed efficacy when administered at least half an hour before breakfast or taking drinks in the morning.
The use of drugs with orange juice or coffee leads to a decrease in bioavailability values of about 60%.
The average distribution volume in stable conditions (except for bones) is equal to at least 28 liters. Plasma drug level after oral administration of therapeutic portions is too low for analytical determination (below 5 ng / ml). Intlasma protein binding is about 78%. It is subjected to a temporary distribution inside the soft tissues, after which it is redistributed at high speed inside the bones (by 30-40% of the administered dosage) or excreted in the urine. In the metabolic processes is not involved.
Excretion is done mainly through the kidneys. The half-life term is ~ 72 hours. The final half-life period may be more than 10 years due to the release of the active element from the skeleton.
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Dosing and administration
For a week it is required to apply 70 mg of the substance (corresponding to the 1st tablet). The drug is consumed in the morning, with water, at least half an hour before breakfast, taking any drinks or drugs. This is due to the fact that food and various drinks (among which mineral water) reduce the absorption of alendronate Na.
To simplify the passage of drugs inside the stomach and reduce local irritation in the area of the esophagus, the drug is used exclusively in the morning, after waking up, while drinking down a pill of 0.2 liters of plain water. It is impossible to dissolve or chew it.
The patient should not take a horizontal position for at least half an hour after drug administration. It is forbidden to take drugs before bedtime or from the morning before getting out of bed.
If a lack of calciferol and calcium is found in the diet, it is necessary to take them additionally.
It is forbidden to prescribe medication to people with poor renal function in the severe stage - the values of CF are <35 ml per minute.
The therapeutic cycle lasts 2-3 + years. After 3 years of therapy, the portion of the drug is reduced (taking the 1st pill in 14 days).
Use Alendros 70 during pregnancy
It is forbidden to appoint Alendros 70 pregnant.
When using drugs during lactation, you need to abandon breastfeeding for the period of treatment.
Contraindications
The main contraindications:
- hypocalcemia;
- anomalies affecting the esophagus, and other factors that prevent the movement of food within the esophagus (achalasia or stricture);
- severe intolerance associated with alendronate or other elements of the drug;
- failure of renal function in the severe stage.
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Side effects Alendros 70
Among the side effects:
- problems with the gastrointestinal tract: diarrhea, nausea, melena, constipation, vomiting, abdominal pain, flatulence and dyspepsia. In addition, gastritis, dysphagia, an ulcer inside the esophagus, esophagitis or erosion of the esophageal nature, belching with acidic gastric contents and distension of the abdomen;
- ODA dysfunction: pain developing in the area of muscles, bones or joints;
- HC lesions: headaches;
- immunity disorders: itching, rash, or erythema;
- signs from the senses: scleritis or uveitis, as well as episcleritis;
- epidermal manifestations: data on the single development of severe epidermal symptoms, including PET and SSD.
Overdose
Signs of poisoning: hypocalcemia or phosphatemia, and disorders in the upper gastrointestinal tract (heartburn, ulcers, gastritis, nausea, and esophagitis).
There are no data on any specific procedures for the treatment of alendronate intoxication. To synthesize alendronate, you must take antacids or drink milk. Due to the high probability of irritation of the esophagus, it is impossible to induce vomiting. Also, the patient must be in an upright position.
Interactions with other drugs
Use with food or drink (also with mineral water), antacids, Ca additives, and individual drugs for ingestion may lead to a decrease in alendronate absorption. Because of this, the patient must wait at least 1 hour before taking other substances.
During clinical trials, estrogen was administered to patients along with Alendros 70. Data on the development of negative reactions have been reported.
With the introduction in combination with NSAIDs, the potentiation of the gastrotoxic properties of alendronate occurs.
Application for children
Because the medication is prescribed only to women during postmenopause, it is not used in pediatrics.
Analogs
Analogs of drugs are drugs Alendon, Osteofos, Ost, Lindron with Alendronat, and in addition Alendra, Recostin, Asko-Sanovel, Osteo-Mef with Fosalen and Londromax with Ostemax. Also on the list are Ostalon, Ralenost and Fosavans with Fosamax.
Attention!
To simplify the perception of information, this instruction for use of the drug "Alendros 70" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.