Alendros 70

Alendros 70 is a medication that changes the mineralization processes and structure of bones. Contains bisphosphonates.

Alendronate Na slows down bone resorption involving osteoclasts, without directly affecting the process of bone formation. Preclinical tests revealed preferential localization of the substance in areas with active resorption processes. The drug slows down osteoclast activity without affecting osteoclast synthesis and accumulation. Bones formed with the use of alendronate are of fairly high quality.

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Indications Alendros 70

It is used in women in case of postmenopausal osteoporosis.

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Release form

The medicine is released in tablets - 2 pieces inside a blister pack. There are 1, 2, 4 or 6 such packs in a box.

Pharmacokinetics

When administered orally, the bioavailability of alendronate was 0.64% at doses of 5-70 mg taken on an empty stomach 2 hours before breakfast. Bioavailability values decreased with this pattern to approximately 0.46% and 0.39% when the drug was administered 1 hour or 30 minutes before breakfast. In osteoporosis testing, the drug was effective when administered at least 30 minutes before breakfast or morning beverages.

Taking the drug with orange juice or coffee results in a decrease in bioavailability values by approximately 60%.

Average distribution volume values under steady state conditions (except for bones) are at least 28 l. Plasma drug levels after oral administration of therapeutic doses are too low for analytical determination (below 5 ng/ml). Intraplasmic protein binding is about 78%. It is temporarily distributed within soft tissues, after which it is redistributed within bones at high speed (by 30-40% of the administered dosage) or excreted in urine. It does not participate in metabolic processes.

Excretion occurs primarily through the kidneys. The half-life is ~72 hours. The terminal half-life may be greater than 10 years due to the release of the active ingredient from the skeleton.

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Dosing and administration

It is necessary to use 70 mg of the substance per week (corresponds to 1 tablet). The medicine is used in the morning with water, at least half an hour before breakfast, taking any drinks or medicines. This is due to the fact that food and various drinks (including mineral water) reduce the absorption of alendronate Na.

To facilitate the passage of the drug into the stomach and reduce local irritation in the esophagus area, the drug is taken exclusively in the morning, after waking up, while washing down the tablet with 0.2 l of plain water. It cannot be sucked or chewed.

The patient should not assume a horizontal position for at least half an hour after the drug is administered. It is prohibited to take the drug before going to bed or in the morning before getting out of bed.

If there is a deficiency of calciferol and calcium in the diet, it is necessary to take them additionally.

It is prohibited to prescribe the medication to people with severe renal insufficiency – the CF values are <35 ml per minute.

The therapeutic cycle lasts 2-3+ years. After 3 years of therapy, the dose of the medication is reduced (taking 1 tablet every 14 days).

Use Alendros 70 during pregnancy

It is prohibited to prescribe Alendros 70 to pregnant women.

When using the drug during lactation, you should stop breastfeeding for the duration of treatment.

Contraindications

Main contraindications:

• hypocalcemia;
• anomalies affecting the esophagus and other factors that prevent the movement of food within the esophagus (achalasia or stricture);
• severe intolerance associated with alendronate or other components of the drug;
• severe renal failure.

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Side effects Alendros 70

Side effects include:

• problems with the gastrointestinal tract: diarrhea, nausea, melena, constipation, vomiting, abdominal pain, flatulence and dyspepsia. In addition, gastritis, dysphagia, ulcers inside the esophagus, esophagitis or erosion of the esophageal nature, belching of acidic gastric contents and abdominal distension;
• dysfunction of the musculoskeletal system: pain developing in the area of muscles, bones or joints;
• nervous system lesions: headaches;
• immune-related disorders: itching, rash or erythema;
• signs from the sensory organs: scleritis or uveitis, as well as episcleritis;
• Epidermal manifestations: data on the isolated development of severe epidermal symptoms, including TEN and SJS.

Overdose

Signs of poisoning: hypocalcemia or -phosphatemia, as well as disorders in the upper gastrointestinal tract (heartburn, ulcers, gastritis, nausea and esophagitis).

There are no specific treatment procedures for alendronate intoxication. To synthesize alendronate, it is necessary to take antacids or drink milk. Due to the high probability of esophageal irritation, vomiting should not be induced. The patient should also be in an upright position.

Interactions with other drugs

Use with food or drinks (including mineral water), antacids, calcium supplements and certain oral medications may reduce the absorption of alendronate. Therefore, the patient should wait at least 1 hour before taking other substances.

During the clinical trials conducted, patients were given estrogen together with Alendros 70. No data were received regarding the development of negative reactions.

When administered in combination with NSAIDs, the gastrotoxic properties of alendronate are potentiated.

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Storage conditions

Alendros 70 should be stored in a place closed to children. Temperature values - not higher than 30°C.

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Shelf life

Alendros 70 can be used for a period of 36 months from the date of manufacture of the medicinal substance.

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Application for children

Because the medication is prescribed only to women during postmenopause, it is not used in pediatrics.

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Analogues

Analogues of the drug are Alendon, Osteofos, Ost, Lindron with Alendronate, and also Alendra, Rekostin, Asco-Sanovel, Osteo-Mefa with Fosalen and Londromax with Ostemax. Also on the list are Ostalon, Ralenost and Fosavance with Fosamax.

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