Alendronate-fatigue

Alendronata-stoma is a drug that affects bone mineralization.

The alendronate Na component slows down bone resorption; This is an artificial analogue of pyrophosphate. The drug inhibits the activity of osteoclasts, slows bone resorption, synthesizes hydroxyapatite inside the bones, which leads to stabilization of the positive balance between bone resorption and recovery. At the same time, the mineral density in the pelvic bone area with the spine and so on increases.

The drug helps to form bone tissue with a healthy histological structure.

[1], [2], [3], [4]

Indications Alendronate-fatigue

It is used in such situations:

• prevention and therapy in the case of osteoporosis (with postmenopausal women or to increase bone mass in men);
• therapy for osteoporosis associated with the use of corticosteroids (men and women);
• Paget's disease. 

[5], [6]

Release form

The release of therapeutic agent is produced in tablets - 10 or 30 pieces inside the box.

[7], [8], [9]

Pharmacokinetics

The absorption of the drug is carried out inside the digestive tract - by 25%. The absolute bioavailability of a serving of 10 mg (corresponding to the 1st tablet) taken 120 minutes before a meal is 0.78% (for women) and 0.59% (for men). At a dosage of 40 mg is 0.6% (for women). With intraplasma protein element binds to 78%. The plasma level of the drug after administration of the therapeutic dosage is below 5 ng / ml.

For some time, the element is distributed inside the soft tissues, and then at high speed it is redistributed inside the bones (30-40% of the portion) or excreted with the urine. In the exchange process is not involved.

Excretion is realized through the kidneys. The level of intrarenal clearance is 71 ml per minute, and the total - 200 ml per minute. The term half-life is a maximum of 10 hours. In the final stage, the term half-life can last more than 10 years - due to the fact that the active component is released from the bones. A large amount of substance accumulates inside the bone tissue.

In the case of the use of a drug immediately before a meal, with it or immediately after it, the values of its bioavailability decrease. Consumption with orange juice or coffee reduces bioavailability by approximately 60%.

[10], [11], [12], [13], [14]

Dosing and administration

Drug should be taken orally; pills do not dissolve or chew. Reception is made on an empty stomach, for 0,5-1 hour before the first use of food; pill washed down with plain water (1 full glass).

Adults need to take 10 mg of the substance per day (1 tablet). In the case of Paget's disease - 40 mg each (corresponding to 4 tablets) for six months.

For the treatment of osteoporosis requires a longer cycle - 2-3 + years. After 3 years of therapy, the dose of medication per day is reduced to 5 mg.

Persons with moderate renal impairment (CC level - in the range of 35-60 ml per minute) and the elderly do not need to change the size of the dosage.

After taking Alendronat-stoma, the patient needs to stay in a vertical state for at least half an hour (it is forbidden to lie down).

[19],

Use Alendronate-fatigue during pregnancy

You can not use the drug during pregnancy. At the time of therapy, breastfeeding should be stopped during lactation.

Contraindications

Among the contraindications:

• strong personal sensitivity to medication;
• esophageal diseases that make it difficult to remove the contents from it (achalasia or strictures);
• lack of kidney function in severe;
• the inability of the patient to sit straight or stand for at least half an hour;
• hypocalcemia.

[15], [16], [17]

Side effects Alendronate-fatigue

Main adverse symptoms:

• dyspepsia, bloating, pain in the abdominal area, constipation, erosion or ulcers affecting the esophagus, diarrhea and dysphagia;
• decrease in serum values of phosphorus and calcium or esophagitis;
• headaches;
• erythema or rash;
• myalgia.

[18]

Overdose

Signs of poisoning: hypophosphatemia or -calcemia, and in addition gastritis, diarrhea or esophagitis, as well as ulcers or erosion that occur in the area of the gastrointestinal tract.

The victim needs to take antacid orally or drink milk - to synthesize alendronate. He also needs to be upright all the time. Symptomatic interventions are carried out. Induce vomiting can not, because it can lead to irritation of the esophageal mucosa.

[20]

Interactions with other drugs

Combination with other medicines for oral administration (among them calcium-containing substances and antacids) leads to a decrease in the intensity of absorption of alendronate. Because of this, it is necessary to withstand at least half an hour the gap between the use of these drugs.

The use of NSAIDs causes the potentiation of gastrotoxic activity of alendronate.

[21], [22], [23], [24]

Storage conditions

Alendronata-stoma must be kept in a dark and dry place closed to small children. Temperatures are in the range of 15-25 ° C.

[25], [26], [27],

Shelf life

Alendronata-stoma is allowed to be used within a 3-year term since the sale of the drug element.

[28], [29], [30]

Application for children

It is forbidden to use Alendronata-stoma in pediatrics.

[31], [32]