Akkupro

Akkupro is a drug from the ACE inhibitor group.

Indications Akkupro

It is used to treat:

• increased values of blood pressure, having a renovascular form;
• deficiency of renal function developing due to scleroderma;
• HSN;
• in the period after myocardial infarction - in combination with other medications.

Release form

The release of medication is done in tablets.

Pharmacodynamics

The active ingredient of the drug is the substance of quinapril. The therapeutic effect is based on competitive blocking of ACE activity and a decrease in angiotensin-1 conversion rate in angiotensin-2.

The drug increases tolerance of the organism in relation to loads and IOC, and besides it weakens afterload and wedging pressure inside the capillaries of the lungs.

Prolonged treatment leads to the reverse appearance of myocardial hypertrophy in people with elevated values of blood pressure, and with ischemic or damaged myocardium - to an improvement in blood flow.

Medication can potentiate coronary circulation and blood flow inside the kidneys, as well as reduce platelet aggregation.

Pharmacokinetics

After a single use of the drug, the drug effect is manifested after 60 minutes. A full medicinal effect is observed during several weeks of therapy.

Dosing and administration

You need to take the pill orally. The size of the initial portion with increased blood pressure is 10 mg (one or two uses). If this portion is ineffective, it is gradually increased to 20 mg (during the 21st day).

On average, the drug dose is approximately 10-20 mg per day. The maximum allowable dosage per day is 80 mg.

Older people, as well as those who suffer from kidney diseases, need to reduce the daily dosage to 5 mg.

Use Akkupro during pregnancy

It is forbidden to assign Accupro to pregnant women.

Contraindications

The main contraindications:

• the presence of hypersensitivity to ACE inhibitors, as well as quinapril;
• the period of lactation.

Caution and preliminary consultation with a doctor is required for such violations:

• idiopathic edema of a hereditary character;
• pathology of cardiovascular or cerebrovascular nature;
• diabetes;
• common autoimmune diseases in the field of connective tissues, which have a severe degree of severity (such as SLE and scleroderma);
• stenosis of the aortic aorta;
• gingivitis;
• arterial stenosis in the area of 2 kidneys;
• in the period after operations during which the kidney transplant was performed;
• diseases affecting the hepatic or renal system;
• aged people;
• vomiting or diarrhea.

Side effects Akkupro

The use of medication can cause various negative symptoms:

• disturbances of CAS function: orthostatic hypotension, myocardial infarction, ischemic stroke, progression of Raynaud's syndrome, tachycardia and worsening of IHD;
• problems with the activities of the National Assembly: the state of depression, fainting, severe fatigue, mood lability, sensitivity disorders, headaches, sleep problems, paresthesia in the limbs, dizziness, and a sense of confusion and asthenia;
• disorders of the sense organs: ear noise, loss of taste perception, vestibular disorders and problems with visual perception;
• digestive disorders: disorders of pancreatic function, constipation, dry mouth mucosa, diarrhea, epigastric pain, weakening of appetite, liver disease, increased level of hepatic enzymes and hyperbilirubinemia;
• problems with hematopoietic function: the development of anemia, pancito-leuko- or neutropenia, as well as agranulocytosis;
• disorders of respiratory function: bronchitis, bronchial spasms, runny nose, sinusitis and dry type cough;
• symptoms affecting the urogenital system: retention of urination, weakening of potency, increased urea, hypercreatininaemia and proteinuria;
• Other: glossitis, hyponatremia, MEE, pruritus, allergy symptoms, hyperkalemia, photosensitivity, myalgia, alopecia, exfoliative form of dermatitis, hyperthermia and arthralgia.

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Overdose

Intoxication causes a significant decrease in blood pressure, development of dizziness or weakness, as well as a disturbance of visual perception.

Symptomatic measures are required to eliminate symptoms.

Interactions with other drugs

The drug potentiates the effect of ethyl alcohol.

Use together with immunosuppressants, allopurinol, and in addition procainamide and cytostatics increases the likelihood of occurrence of leukopenia.

The drug increases the antidiabetic effect of sulfonylurea and its derivatives, as well as insulin.

Diuretics, opiates, drugs for general anesthesia and antihypertensive drugs potentiate the hypotensive effect of Accupro.

The use of NSAIDs or table salt leads to a decrease in drug efficacy.

Potassium-sparing diuretics (including amiloride and triamterene with spironolactone) and potassium drugs lead to the development of hyperkalemia.

When using estrogens, there is a decrease in antihypertensive properties of the drug - due to fluid retention within the body.

When combined with drugs that suppress bone marrow function, the probability of neutropenia or agranulocytosis increases.

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Storage conditions

Accupro should be kept out of the reach of children. The temperature is not higher than 25 ° C.

Shelf life

Akkupro is allowed to be used within 36 months after the release of the therapeutic agent.

Analogues

The analogues of the medication are Acurenal preparations, and also Quinafar.