Akinotene

Akineton is an antiparkinsonian drug.

Indications Akineton

It is used for extrapyramidal disease, triggered by the use of antipsychotics (antipsychotics) against a background of trembling paralysis and parkinsonism.

[1], [2]

Release form

The release of the substance is realized in solution or tablets.

[3], [4]

Pharmacodynamics

The active ingredient is biperiden - holinoblokator with the central type of medicamentous influence.

The therapeutic effect develops by suppressing the activity of cholinergic neurons inside the structural element - the striatum of the brain. The drug has a ganglion-blocking effect, but in addition it has spasmolytic and moderate m-holinoblocking properties of the peripheral type.

Akineton has the ability to eliminate rigidity of muscles and catalepsy, triggered by the use of neuroleptics, and in addition to tremor of the extremities due to the use of cholinergic drugs (such as pilocarpine).

Medication can lead to the development of psychomotor agitation.

[5], [6]

Dosing and administration

The drug solution is administered intravenously or intramuscularly, and the tablets are taken orally. Dosage sizes are selected separately for each patient.

For the treatment of extrapyramidal disease due to the use of antipsychotics (antipsychotics): the administration of / m or IV with the method of 2 mg of the drug. Enter this portion repeatedly after every 30 minutes, but no more than 4 times / day. Tablets should be consumed in the amount of 2 mg 1-3 times a day.

To treat tremor paralysis, 2 mg of the drug should be taken orally 2-4 times a day. This portion is gradually increased to 6-16 mg.

[12], [13], [14], [15],

Use Akineton during pregnancy

Akineton with great caution can be used in pregnant women or lactating women.

Contraindications

Among the contraindications:

• hypersensitivity to the element biperiden;
• megakolon;
• glaucoma, having a closed-angle shape;
• hyperplasia of the prostate;
• presence of intestinal blockage.

Caution is required when used in persons suffering from epilepsy or arrhythmia, and in addition to the elderly.

Side effects Akineton

The use of the drug can provoke such side effects: the appearance of hallucinations, constipation, dryness of the oral mucosa, dyspeptic disorders and dizziness. In addition, paresis of accommodation, a feeling of quick fatigue, drowsiness, confusion, anxiety or weakness can occur. Catalepsy, delayed urination, decreased blood pressure and signs of allergy may also occur.

[7], [8], [9], [10], [11]

Overdose

Intoxication with medicament causes the appearance of strongly expressed holinoblokiruyuschih signs.

To eliminate them, you must enter substances that slow the activity of cholinesterase, as well as carry out symptomatic procedures.

[16], [17], [18], [19], [20]

Interactions with other drugs

Akineton potentiates the effect of anticonvulsants, antihistamines and anti-Parkinsonics, as well as m-holinoblokatorami. In doing so, it reduces the therapeutic effect of metoclopramide.

Use with quinidine increases the likelihood of dyskinesia.

When combined with levodopa, the intensity of m-cholinergic action is potentiated.

The drug is not compatible with ethyl alcohol.

[21], [22], [23], [24], [25]

Storage conditions

Akineton is required to be kept in a place where access to small children is denied. Temperature values are not higher than 25 ° C.

[26],

Shelf life

Akineton is allowed to be used within 5 years from the date of release of the therapeutic agent.

[27], [28], [29]

Analogues

Analogues of the drug are Biperiden and Mendilex with Biperiden hydrochloride.

[30], [31], [32], [33], [34], [35]

Reviews

Akineton has a high effectiveness in the treatment of parkinsonism, eliminating tremor of the extremities in a short time interval. In addition, it is noted that it is well tolerated.

In some reviews, patients say that the medication causes the development of negative symptoms.