Agicold

There are many drugs for the rapid treatment of colds. Adzhikold is one of the most effective, let's look at its instructions.

Adzhikold is a medicinal product with a local irritant effect, used for symptomatic therapy of colds and rheumatic back pain. It has analgesic and antipyretic properties. It has several forms of release, which allows it to be prescribed to patients of different age groups.

The medication contains several active components: paracetamol, phenylephrine hydrochloride, ascorbic acid. Their complex effect on the body normalizes general well-being in respiratory pathologies.

Indications Agicold

The main indications for the use of Adzhikold are the treatment and prevention of colds. The drug helps with headaches, nasal congestion and runny nose, muscle and joint pain, as well as fever and chills.

Release form

The anti-cold remedy is available in several forms:

• Ointment for external use
• Powder for solution preparation
• Pills
• Vegetable syrup

Each of them contains: paracetamol, phenylephrine hydrochloride, ascorbic acid, caffeine and excipients. The choice of dosage form depends on the patient's age and cold symptoms.

Adzhikold ointment

An effective local irritant with anti-cold properties is Adzhikold ointment. It contains the following substances: camphor 70 mg, racemic menthol 60 mg, eucalyptus essential oil 30 mg and thymol 15 mg. It is produced in plastic containers of 20 g, which are packed in cardboard boxes.

• Indications for use: infectious and inflammatory diseases of the lower and upper respiratory tract, which are accompanied by cough, runny nose, nasal congestion. Muscle and joint pain, neuralgia.
• The product is intended for external use. In case of a cold, a small amount of ointment should be applied to the chest, neck, and back twice a day, rubbing vigorously. In case of neuralgia and muscle pain, the ointment is applied to painful areas. After rubbing, the treated areas should be wrapped. To eliminate rhinitis, 1 spoon of ointment should be dissolved in 250 ml of hot water and use the product for inhalation twice a day.
• Side effects occur with individual intolerance to the components of the product. This manifests itself in the form of allergic reactions, including contact dermatitis. If the drug is accidentally taken orally, attacks of nausea and vomiting, diarrhea, and increased drowsiness may occur.
• Contraindications: patients under 2 years of age, tendency to bronchospasms, convulsions, damage to the skin at the site of application, hypersensitivity to the components of the ointment. The drug is prescribed with special caution during pregnancy and lactation. It is prohibited to treat mucous membranes, especially the oral cavity and nose.
• Overdose does not occur when applied externally. If the medicine is ingested, it causes nausea, vomiting, headaches and abdominal discomfort, severe dizziness and facial flushing, convulsions, CNS depression, and difficulty breathing. To eliminate these reactions, it is necessary to wash out the stomach, take activated charcoal or a saline laxative. In case of severe convulsions, intravenous administration of diazepam or short-acting barbiturates is recommended.

Ajicold herbal syrup

A combination drug used for colds and coughs is Adzhikold herbal syrup. The effectiveness of the medicine is due to its composition. The syrup has mucolytic properties, that is, it helps to thin and remove phlegm, reduces swelling and hyperemia of the throat mucosa, facilitates breathing, and reduces bronchospasms.

• Indications for use: symptomatic and complex therapy of inflammatory diseases of the respiratory tract with cough (pharyngitis, tracheitis, bronchitis, laryngitis, pneumonia). The main contraindication is hypersensitivity to the components of the drug.
• The dosage depends on the severity of the pathological condition and the age of the patient. For children 3-5 years old, 2.5 ml of syrup is prescribed 3 times a day, for children 6-14 years old, 2.5-5 ml 3 times a day, for children over 14 years old and adults, 5-10 ml 3 times a day. The duration of treatment is 2-3 weeks.
• Side effects are rare and manifest themselves as allergic reactions that disappear after discontinuing the drug. Overdose manifests itself as painful symptoms in the epigastric region, attacks of nausea and vomiting. Symptomatic treatment is indicated to eliminate it.

Ajicold tablets

For the rapid elimination of colds, correct and timely treatment is very important. Adzhikold tablets are recommended to be taken at the first signs of malaise. The drug is available in blisters of 4 and 10 tablets. Each tablet contains 500 mg of paracetamol, 30 mg of caffeine, 10 mg of phenylephrine hydrochloride and 2 mg of chlorpheniramine maleate.

• Indications for use: elimination of flu and cold symptoms, relief of headaches, muscle and joint pain, nasal congestion and runny nose, lacrimation, chills. Dosage for adult patients - 2 tablets 2-4 times a day, for children aged 6-12 years - 1 capsule up to 4 times a day, observing an interval of 4-6 hours. The course of treatment should not exceed 5-7 days.
• Side effects occur in isolated cases. Patients experience various allergic reactions, skin rashes, nausea, and pain in the epigastric region. Sleep disturbances, dry mouth, headaches, and increased nervous excitement are also possible.
• The main contraindication for use is intolerance to the components of the drug. Adzhikold is contraindicated in severe renal and hepatic dysfunction, during pregnancy and lactation, in severe forms of diabetes mellitus, acute pancreatitis, hyperthyroidism and for children under 6 years of age.
• Overdose may occur due to the action of paracetamol. It manifests itself as pronounced pallor of the skin, nausea, vomiting, increased activity of liver transaminases. Symptomatic therapy, gastric lavage and administration of activated carbon are indicated for treatment.

Adjicold hotmix

Another popular form of cold medicines is powders for making solutions with different flavors. Adzhikold Hotmix has an orange flavor and is available in packages of 5, 10 and 50 sachets of 5 g each. The granulated powder contains the same active ingredients as other forms of the drug, i.e.: paracetamol, caffeine, phenylephrine hydrochloride, chlorpheniramine maleate.

• It is used for symptomatic treatment of colds and infectious and inflammatory diseases, which are accompanied by headaches and muscle pain, fever, nasal congestion and acute rhinitis. The medicine is taken 1 sachet 4 times a day. The contents of the bag must be poured into a glass and filled with 200-250 ml of hot water.
• Side effects: increased fatigue, decreased speed of psychomotor reactions, dry mouth, temporary increase in blood pressure and increased heart rate, epigastric pain, urinary retention.
• Contraindications: hypersensitivity to paracetamol or any other components of the drug, patients under 15 years of age, hyperoxaluria. Do not use with tricyclic depressants or monoamine oxidase inhibitors.
• The drug should be prescribed with special caution in the presence of the following systemic manifestations: hypertension, bradycardia, pregnancy and lactation, hyperthyroidism, prostatic hypertrophy, recent myocardial infarction or unstable angina.
• Overdose: loss of appetite, pale skin, liver necrosis, nausea and vomiting. A more pronounced toxic effect occurs with a single use of 10-15 g of the drug. In this case, emergency medical care is indicated with gastric lavage and monitoring of vital signs.

Pharmacodynamics

Ajikold is a combination drug, as it contains several components. Pharmacodynamics is determined by the following substances:

• Paracetamol is an antipyretic and analgesic agent. It reduces the excitability of the hypothalamic thermoregulatory center and participates in the inhibition of prostaglandin synthesis.
• Phenylephrine hydrochloride is a vasoconstrictor that works to relieve nasal congestion and reduce discharge from the sinuses.
• Caffeine is a stimulant that affects the central nervous system, reduces the feeling of drowsiness and fatigue. Increases mental and physical performance.
• Chlorpheniramine maleate is an anti-edematous and anti-allergic agent. Its action is aimed at reducing vascular permeability. It relieves swelling and redness of the nasal mucosa. It eliminates the symptoms of allergic rhinitis and facilitates nasal breathing.

Pharmacokinetics

The anti-cold remedy begins to act 30 minutes after application, providing an antipyretic and analgesic effect. Pharmacokinetics is expressed by the following components:

• Paracetamol is rapidly absorbed from the gastrointestinal tract and binds to plasma proteins. The maximum plasma concentration is observed after 1-4 hours. Metabolizes in the liver, forming paracetamol glucuronide sulfate. The metabolic process is associated with general clearance and the microsomal enzyme system. Penetrates the placental barrier. Glucuronidation products have nephrotoxic and hepatotoxic properties. The substance is excreted as conjugation products, about 5% is excreted unchanged.
• Phenylephrine hydrochloride is poorly absorbed from the gastrointestinal tract, metabolized during the first pass through the liver by monoamine oxidase in the intestinal walls. Undergoing biotransformation, it forms a sulfated derivative - phenylephrine 3-O-sulfate. Bioavailability is low, undergoes systemic absorption.
• Chlorpheniramine maleate is completely and quickly absorbed from the gastrointestinal tract and distributed throughout the body tissues. About 70% of the substance binds to plasma proteins. The half-life is 8 hours. Metabolizes in the liver. Gradually absorbed from the gastrointestinal tract, the maximum concentration in the blood plasma occurs after 3-6 hours. Excreted in the urine, part unchanged and part of the substance in the form of dimethylated metabolites. The rate of excretion depends entirely on the pH of the urine.
• Caffeine is rapidly absorbed, the maximum concentration in the blood plasma is reached 5-90 minutes after oral administration. It is rapidly destroyed in cells, penetrates the placental and blood-brain barrier. About 35% binds to blood plasma proteins. It is rapidly metabolized in the liver, forming metabolites: 1-methyluric acid, 1-methylxanthine and 7-methylxanthine. All metabolites undergo intensive biotransformation, the elimination period is about 5 hours. It is excreted by the kidneys.

Dosing and administration

The anti-cold remedy has several forms of release, on which the method of application and dosage depend. Adzhikold is prescribed according to the following schemes:

• Tablets – adults 2 pcs. 1-4 times a day, for children 1 pc. 1-4 times a day. The course of treatment is 5-7 days.
• Ointment - intended for external use and inhalation for rhinitis. A small amount of the medicine should be spread over the neck, back, chest and rubbed well. After rubbing, wrap up and stay warm.
• Syrup – for children aged 3-14 years, ½ - 1 teaspoon 3 times a day, for patients over 14 years old and adults, 1-2 spoons 3 times a day. Duration of treatment is 14-21 days.
• Powder for solution preparation – the contents of one sachet must be poured with hot water and stirred until completely dissolved. The medicine is recommended to be used one sachet up to 4 times a day. The course of treatment should not exceed 5 days.

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Use Agicold during pregnancy

The possibility of using Adzhikold during pregnancy should be determined by the attending physician. This is due to the fact that some substances included in the drug can penetrate the placental barrier. The drug is prescribed in the case when the potential benefit to the mother is higher than the possible risks to the fetus.

Contraindications

Effective elimination of colds depends entirely on the drugs chosen. Adzhikold is a combination drug, but despite its effectiveness, it has the following contraindications for use:

• Intolerance to the components of the drug.
• Pregnancy and breastfeeding.
• Patients are under 6 years of age.
• Concomitant use with medications that contain the active ingredients of Adzhikold.
• Concomitant use with tricyclic antidepressants, beta-blockers and monoamine oxidase inhibitors.

The drug is prescribed with special caution to patients with blood diseases, liver or kidney failure, arterial hypertension, thyroid gland damage. And also with diabetes mellitus, bronchial asthma, closed-angle glaucoma.

Side effects Agicold

Misuse of cold medicine causes side effects. Ajikold can cause the following symptoms:

• Allergic reactions (itching, rash, burning, urticaria, angioedema).
• Headaches and dizziness, increased excitability.
• Sleep disorders.
• Attacks of nausea and vomiting, dry mouth.
• Pain in the epigastric region.
• Anemia and thrombocytopenia.
• Increased arterial and intraocular pressure.
• Urinary retention.

If the drug is used for a long period of time and in doses exceeding the recommended ones, hepatotoxicity, nephrotoxicity, aplastic or hemolytic anemia may occur.

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Overdose

The medicine must be used in the dosages prescribed by the doctor. Failure to follow the treatment recommendations may cause adverse symptoms. Overdose in most cases is associated with the action of paracetamol. Attacks of nausea and vomiting, pronounced pallor of the skin, increased activity of liver transaminases and increased heart rate appear. To eliminate these reactions, it is necessary to wash the stomach, take activated charcoal and, if necessary, conduct further symptomatic therapy.

Interactions with other drugs

For fast and effective treatment of colds, a comprehensive approach is recommended. Interactions of Adzhikold with other drugs should be monitored by the attending physician. This is due to the high risk of developing adverse reactions from many organs and systems.

• The drug is not recommended to be taken with other medications that contain paracetamol.
• The drug enhances the effect of MAO inhibitors, ethanol and sedatives.
• When used with antidepressants, antipsychotics, antiparkinsonian and phenothiazine derivatives, the risk of developing constipation, dry mouth and fluid retention in the body increases.
• When interacting with glucocorticosteroids, the risk of developing glaucoma increases.
• Paracetamol slows down the action of diuretics.
• Chlorpheniramine in combination with MAO inhibitors may cause hypertensive crisis and hyperpyrexia.
• Tricyclic antidepressants increase their symptomatic effect.
• Halothane increases the risk of developing ventricular arrhythmia.

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Storage conditions

Regardless of the form of release, the drug, according to storage conditions, must be kept in a place protected from sunlight, moisture and inaccessible to children. The recommended storage temperature should not exceed 25 °C.

Shelf life

Adzhikold must be used within 36 months from the date of manufacture. The expiration date is indicated on the packaging of the drug. Improper storage of the drug reduces its shelf life. Expired drugs are contraindicated and must be disposed of.