Aevit

Aevit is a vitamin complex that has antioxidant and immunostimulating effects.

Indications Aevit

Treatment with Aevit is prescribed to patients who, due to various indicators, require long-term use of vitamins of groups A and E (in large quantities). Among the diseases for which the use of this drug is indicated:

• problems with microcirculation in tissues, as well as their trophism;
• vascular atherosclerosis;
• obliterating form of endarteritis;
• Libman-Sachs disease or psoriasis;
• atrophic processes in the optic nerves, development of hemeralopia, xerous keratitis, and in addition, pigment retinitis.

Aevit should also be used by patients with dietary restrictions and reduced levels of intake (naturally) of vitamins A and E. In addition, for the following diseases and conditions:

• diarrhea;
• gastrectomy;
• fatty feces;
• granulomatous enteritis, malabsorption, celiac disease;
• chronic cholestasis, obstructive jaundice, bile duct obstruction, and liver cirrhosis;
• development of cystic fibrosis;
• acute or chronic forms of infectious pathologies;
• lack of adequate nutrition, rapid weight loss (Aevit is often prescribed to patients on parenteral nutrition - this is necessary to replenish the deficiency of the above vitamins in the body);
• drug addiction, alcoholism or nicotine addiction;
• long-term stress;
• the use of drugs, as well as mineral oils, which contain iron (drugs such as colestipol, neomycin, and cholestyramine);
• a diet in which the body receives a large amount of polyunsaturated fatty acids;
• development of hyperthyroidism;
• polyneuropathy;
• acanthocytosis;
• necrotizing form of myopathy.

Release form

It is produced in the form of capsules. There are 10 capsules on a blister, 1 or 5 blister plates in one package. It can also be produced in 50 capsules on a blister, with 1 blister plate in the package.

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Pharmacodynamics

Vitamins Aevit help to heal tissues, and also help to carry out protein and lipid metabolism. In addition, they have a beneficial effect on the visual organs, the circulatory system, support the reproductive system, and at the same time restore tissue trophism and vascular permeability.

The above-described properties are due to the presence of retinol and, along with it, tocopherol acetate in the composition of the drug, which have such an effect.

Retinol promotes metabolic processes within tissues, and in addition, it enhances humoral and cellular immunity, increases the rate of myelopoiesis and increases the functional activity of macrophages. Thanks to this vitamin, you can reduce the risk of diseases in the mucous membranes of the respiratory tract, and in addition, the digestive system. Retinol also allows you to slow down the processes of keratinization and rejuvenate cells. Along with this, this vitamin has a beneficial effect on the functioning of the reproductive system. Retinol palmitate helps to form bone tissue with a visual signal and has a beneficial effect on bone growth processes. In addition, it has a positive effect on the functioning of the lacrimal, sebaceous, and sweat glands.

Unsaturated molecular bonds of retinol enable it to combine with various types of radicals, as well as stimulate the activity of antioxidant properties of tocopherol. It also subsequently prevents the oxidation processes of retinol, thereby preventing the formation of toxic products in the body.

The function of tocopherol is to help regulate metabolic processes and protect cells from the effects of free radicals. This component also prevents the processes of hemolysis of red blood cells and has a beneficial effect on tissue trophism and microcirculation, and along with this on the vascular system.

Alpha-tocopherol stimulates the immune system (cellular, and with it humoral and general). This element helps to activate the function of T-lymphocytes. At the same time, in combination with retinol, it ensures the natural formation of the reproductive system in the embryo, and also promotes normal embryonic growth and development.

Pharmacokinetics

Retinol is absorbed in the gastrointestinal tract, and vitamin E is absorbed in the digestive tract. Both active components of the drug are evenly distributed within organs and tissues. Excessive amounts of active components are deposited in the liver (retinol and partially tocopherol) and adrenal glands, along with erythrocytes, fatty and muscle tissue, and also in the testicles (tocopherol acetate).

When retinol is metabolized in the liver, both active and inactive decay products are formed. Metabolism of vitamin E leads only to the formation of pharmacologically inactive decay products.

Retinol is excreted from the body as decay products along with bile and urine. This is a slow process – after a single dose, 1/3 of the consumed vitamin is excreted within 3 weeks. Tocopherol is excreted exclusively with bile. A small amount of the substance is excreted with urine.

Dosing and administration

Vitamins should be taken after meals, swallowing them whole, without chewing, and washed down with plain water.

For an adult, the average course of treatment is 30-40 days (take 1 capsule once a day). The attending physician may also prescribe individual doses for patients.

In order to more accurately prescribe a dosage of a drug or conduct a repeat course of treatment (the latter is allowed at least 3-6 months after the completion of the last course), the doctor needs to know the exact characteristics of the patient's body, as well as the nature of his illness.

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Use Aevit during pregnancy

The use of Aevit during lactation or pregnancy is permitted only with the prescription of the attending physician.

Contraindications

Among the contraindications:

• the patient has an individual intolerance to the active components of the drug;
• chronic form of glomerulonephritis and circulatory failure, and in addition thyrotoxicosis;
• myocardial infarction, severe atherosclerosis in the coronary arteries, risk of thromboembolism, and in addition, acute or chronic inflammatory processes in the kidneys (in this case, the drug can be prescribed with caution).

Side effects Aevit

The use of vitamins Aevit can lead to the following side effects:

• allergy symptoms, nausea with vomiting, upset stomach or gastralgia - develop sporadically, usually due to the individual characteristics of the patient's body;
• exacerbation of chronic pancreatitis or cholelithiasis - in people who have been taking Aevit for a long time;
• hypervitaminosis type A. Its manifestation is damage to the central and peripheral nervous systems, as a result of which the patient experiences problems with sleep, headaches, a feeling of irritability or apathy, as well as paresthesia. Skin damage is also possible - dryness in the area of the palms and feet, as well as cracks on them, the development of alopecia or seborrhea.

There are also reports of an increase in the size of the spleen, pain in the joints, and, in addition, a change in gait - but these symptoms arose as a result of prolonged use of the drug in high doses.

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Overdose

In case of taking too large doses of the drug, a feeling of drowsiness, headaches, and vision problems may occur. In addition, the level of fluid pressure in the spinal cord may increase sharply (while no pathological changes are observed in the fluid itself). In case of further increase in dosage, convulsions may occur and heart failure may develop. As a result of prolonged use of the drug in large doses, chronic retinol intoxication may develop. Its symptoms are disorders in the functioning of the central nervous system and the peripheral nervous system, as well as the musculoskeletal system and endocrine glands, and in addition, skin lesions.

There is no specific antidote to eliminate overdose symptoms. If chronic or acute intoxication has developed, discontinue use of the drug and perform symptomatic treatment (if necessary).

Interactions with other drugs

The drug is prohibited to be combined with other drugs that contain retinol, as well as its analogues in synthetic form.

When combining Aevit with estrogens, the risk of developing hypervitaminosis type A may increase, which is why such a combination of drugs is not recommended.

Nitrates, as well as colestyramine in combination with Aevit, slow down the process of absorption of retinol palmitate.

Retinol palmitate in combination with GCS weakens the anti-inflammatory properties of the latter.

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Storage conditions

The medicine should be kept in standard conditions for medicinal products - in a place closed from moisture and sunlight, as well as out of reach of children. The temperature regime is within 15-25 degrees.

Shelf life

Aevit is permitted to be used for 2 years from the date of manufacture of the medicine.