Syndrome of accelerated ESR

When you go to a medical institution for prevention purposes, or when you visit a doctor with complaints, the most common laboratory test is a general laboratory blood test, in our case, a study - ESR, which means the rate of erythrocyte sedimentation. Earlier this method was called ROE - the reaction of erythrocyte sedimentation. ESR is a nonspecific blood indicator and does not indicate the presence of a specific pathology. The norms of ESR indicators may depend on the sex and age of the patient. The most common deviations from the norm are an increased ESR index, or a lowered index of it.

There are cases when the value of ESR indicators is greatly increased for no apparent reason. In medicine, this deviation from the norm is called the accelerated ESR syndrome.

In this article, we offer a more detailed understanding of the causes of the syndrome, as well as its symptoms, treatment and prevention. For this, a little more detailed information about the clinical study of ESR: the laboratory methods of determination, its normal indices.

The most common methods by which it is possible to establish the rate of erythrocyte sedimentation in the laboratory are: the methods of Panchenkov and Westergren. Panchenkov's method is based on the property of aggregates of erythrocytes to settle at a certain rate on the bottom of the vessels. For this study, the capillary blood from the finger is taken, diluted in a special solution of sodium citrate, placed in a glass capillary. For the method of Westergren, venous blood is taken, which is examined in a special laboratory tube 200 mm long.

The following norms of the ESR index are generally recognized

• adult males 1-10 mm / h
• adult women - 15 mm / h
• persons older than 75 years up to 20 mm / h
• children - 3-12 mm / h.

Epidemiology

Medical statistics cite data stating that in 5 10% of healthy people the ESR index may be increased for a sufficiently long time. Older patients with a syndrome can recommend alternative medicine.

[1],

Causes of the accelerated ESR syndrome

Some diseases and pathological conditions of the body give an increase in ESR up to 100 mm / h and above: with genyantritis, acute respiratory viral infection, pneumonia, tuberculosis, bronchitis, cystitis, pyelonephritis, viral hepatitis, malignant tumors. If any first signs of the disease occur, you need to undergo a thorough medical examination.

Increased ESR is often observed with various infections:

• with angina, otitis, sinusitis;
• for respiratory tract infections;
• with urogenital infections;
• with meningitis, tuberculosis, sepsis.

Timely identified disease, the study of its epidemiology and pathogenesis, as well as timely treatment will help to avoid serious consequences and complications.

It is worth noting that sometimes there are cases of elevated ESR in the absence of any visible signs of the disease. This condition in medicine is called the accelerated ESR syndrome. The causes of this syndrome can also be:

• a variety of anemia (this effect occurs when the ratio of the number of plasma and erythrocytes is violated);
• increased concentration of proteins in the blood plasma;
• with renal (acute and chronic) insufficiency in the patients under study, a significant increase in the amount of fibrinogen in the blood plasma is possible);
• increased blood cholesterol levels (especially in severe cases of obesity);
• pregnancy at any time;
• breast-feeding;
• reception of various hormonal preparations;
• a sharp decrease in body weight;
• immune changes after vaccinations and various diseases;
• in old age;
• inaccuracy in the study.

[2], [3], [4]

Symptoms of the accelerated ESR syndrome

Symptoms in the syndrome of accelerated ESR may be absent, and, only, an increased rate of erythrocyte sedimentation rate in the analyzes may indicate the presence of this anomaly. Therefore, the diagnosis of the syndrome can be random, for example, during a preventive medical examination. If after careful examination of the patient no pathologies and diseases are revealed, then the syndrome of accelerated ESR in treatment does not need, because the indicator of ESR is not a pathology in itself. Patients with this anomaly is recommended continuous medical supervision.

[5], [6], [7], [8], [9]

Diagnostics of the accelerated ESR syndrome

Increased ESR can definitely indicate the presence of disease in the body or the onset of the disease. In such cases, re-conduct the analysis. If the previous result is confirmed, the patient needs an additional more thorough examination. To do this, you need to collect a more detailed anamnesis, assign additional tests, perform radiography, ultrasound scanning, ECG, palpation of internal organs, conduct a more thorough external examination, and use other diagnostic methods, study risk factors.

[10], [11]

Differential diagnosis

Differential diagnosis distinguishes such groups of diseases:

• infections, both bacterial and viral;
• various inflammatory processes, local and whole organism;
• at various malignant formations;
• with rheumatism and other autoimmune diseases;
• diseases that were accompanied by tissue necrosis (cerebral strokes, myocardial infarction, tuberculosis)
• with anemia and other blood diseases;
• when injuries, poisonings, long stressful situations;
• disorders and metabolic imbalances (in diabetes mellitus).

Prevention

Prevention in this case can be considered permanent medical supervision and laboratory monitoring of ESR. The prognosis, with proper observance of all medical recommendations, is quite positive.

[12], [13], [14], [15]