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The causes of increase and decrease in thyroid-stimulating hormone

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Last reviewed: 23.04.2024
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With hypothyroidism, the thyroid-stimulating hormone rises. The diagnosis is confirmed by low concentrations of free thyroxine (cT 4 ), T 4, T 3 in the blood. In cases of subclinical mild hypothyroidism, when the level of cT 4 and T 4 in the blood is within normal limits, the detection of an elevated thyroid-stimulating hormone becomes crucial. A low level of thyroid-stimulating hormone in hypothyroidism indicates a deficiency of the pituitary or hypothalamus and excludes primary dysfunction of the thyroid gland. The definition of thyroid-stimulating hormone is important for monitoring patients with hypothyroidism who receive daily substitution therapy with levothyroxine sodium. Determining the concentration of thyroid-stimulating hormone, it is possible to optimize the dose of the drug taken.

With hyperthyroidism, the synthesis and secretion of the thyroid-stimulating hormone are suppressed. As a result, primary hyperthyroidism (thyroid disease) is characterized by an increased content of thyroid hormones (T 4, T 3 ) in the blood and a deficiency of thyroid-stimulating hormone.

The concentration of thyroid-stimulating hormone increases with thyrotropine-secreting tumors of the pituitary gland (in 90% of cases, macroadenomas, a size of more than 10 mm). At the same time, it must be remembered that long-term hypothyroidism can lead to pituitary hyperplasia with the formation of a pseudotumor, and therefore, all patients should be examined the concentration of CT 4 before performing an operation on the pituitary gland . Elevated values of PT 4 testify in favor of pituitary adenoma, low - hypothyroidism.

Diseases and conditions in which the concentration of thyroid-stimulating hormone in the blood serum changes

Increase in the concentration of thyroid-stimulating hormone

Reducing the concentration of thyroid-stimulating hormone

  • Primary hyperthyroidism
  • Hypothalamic-pituitary insufficiency
  • Pituitary Tumor
  • Pituitary Injury
  • Postpartum necrosis of the pituitary gland
  • Isenko-Cushing syndrome
  • The use of acetylsalicylic acid, heparin, thyroid hormones, glucocorticosteroids

trusted-source[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]

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