The causes of increase and decrease in thyroid-stimulating hormone
Last reviewed: 23.04.2024
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With hypothyroidism, the thyroid-stimulating hormone rises. The diagnosis is confirmed by low concentrations of free thyroxine (cT 4 ), T 4, T 3 in the blood. In cases of subclinical mild hypothyroidism, when the level of cT 4 and T 4 in the blood is within normal limits, the detection of an elevated thyroid-stimulating hormone becomes crucial. A low level of thyroid-stimulating hormone in hypothyroidism indicates a deficiency of the pituitary or hypothalamus and excludes primary dysfunction of the thyroid gland. The definition of thyroid-stimulating hormone is important for monitoring patients with hypothyroidism who receive daily substitution therapy with levothyroxine sodium. Determining the concentration of thyroid-stimulating hormone, it is possible to optimize the dose of the drug taken.
With hyperthyroidism, the synthesis and secretion of the thyroid-stimulating hormone are suppressed. As a result, primary hyperthyroidism (thyroid disease) is characterized by an increased content of thyroid hormones (T 4, T 3 ) in the blood and a deficiency of thyroid-stimulating hormone.
The concentration of thyroid-stimulating hormone increases with thyrotropine-secreting tumors of the pituitary gland (in 90% of cases, macroadenomas, a size of more than 10 mm). At the same time, it must be remembered that long-term hypothyroidism can lead to pituitary hyperplasia with the formation of a pseudotumor, and therefore, all patients should be examined the concentration of CT 4 before performing an operation on the pituitary gland . Elevated values of PT 4 testify in favor of pituitary adenoma, low - hypothyroidism.
Diseases and conditions in which the concentration of thyroid-stimulating hormone in the blood serum changes
Increase in the concentration of thyroid-stimulating hormone
- Primary hypothyroidism of the thyroid gland
- Subacute thyroiditis
- Thyroiditis Hashimoto
- Pituitary Tumor
- Ectopic secretion in tumors of the lung, mammary gland
- Endemic goiter
- Inflammation of the thyroid gland
- Condition after iodine therapy
- Thyroid cancer
Reducing the concentration of thyroid-stimulating hormone
- Primary hyperthyroidism
- Hypothalamic-pituitary insufficiency
- Pituitary Tumor
- Pituitary Injury
- Postpartum necrosis of the pituitary gland
- Isenko-Cushing syndrome
- The use of acetylsalicylic acid, heparin, thyroid hormones, glucocorticosteroids
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