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Thyroxine-binding globulin in blood

 
, medical expert
Last reviewed: 05.07.2025
 
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Reference values (norm) for the concentration of thyroxine-binding globulin in the blood serum in adults are 13.6-27.2 mg/l; during pregnancy (more than 5 months) - 56-102 mg/l. The ability of TSH to bind T 4 in adults is 100-250 μg/l.

Thyroxine-binding globulin binds the bulk of T3 ( 80%) (the remaining 20% are transported by albumin and prealbumin - 10% each) and T4 ( 75%). 10% of T4 binds albumin, 15% - prealbumin.

The thyroxine-binding globulin test is useful for the differential diagnosis of changes in T3 and T4 concentrations in primary thyroid diseases and as a result of primary changes in thyroxine-binding globulin .

Diseases and conditions in which the concentration of thyroxine-binding globulin in the blood serum changes

Thyroxine binding globulin is elevated

Thyroxine binding globulin is decreased

Infectious hepatitis

Acute renal failure

Hypothyroidism

Pregnancy

Use of estrogens, phenothiazines, oral contraceptives, methadone

Severe diseases

Surgical stress

Protein deficiency

Malabsorption of various etiologies

Protein-losing enteropathies

Nephrotic syndrome

Active acromegaly

Ovarian hypofunction

Genetic predisposition

Use of androgens, glucocorticosteroids in high doses, corticotropin, phenytoin

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