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Spontaneous lymphocyte blast transformation reaction

 
, medical expert
Last reviewed: 05.07.2025
 
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The magnitude of spontaneous blast transformation of lymphocytes in adults is normally up to 10%.

Spontaneous blast transformation of lymphocytes is the ability of lymphocytes to transform without stimulation. The study is performed to assess the functional activity of T-lymphocytes.

Diseases and conditions in which spontaneous blast transformation of lymphocytes is altered

Increase in the indicator

  • Hyperactivity of the immune system in allergic and autoimmune diseases
  • Activation of anti-transplant immunity
  • Donor Organ Rejection Crisis
  • Acute period of primary infection
  • Immune response to thymus-dependent antigens

Decrease in the indicator

  • Oncological diseases
  • Secondary immunodeficiency states
  • Congenital defects of the immune system, HIV infection
  • Severe viral infections
  • Severe burns, injuries
  • Treatment with cytostatics and immunosuppressants
  • Ionizing radiation
  • Taking glucocorticosteroids

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