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Stimulated blast transformation reaction of lymphocytes with mitogens
Last reviewed: 04.07.2025
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The values of stimulated reaction of blast transformation of lymphocytes in adults are normal: with FGA - 44-72%, with ConA - 40-75%.
The functional activity of T- and B-lymphocytes is assessed by the reaction of blast transformation of lymphocytes using mitogens - PHA, ConA, latex, lipopolysaccharides, etc.
Stimulated blast transformation of lymphocytes with mitogens (PHA, ConA) characterizes the functional ability of T-lymphocytes to transform and multiply under the influence of antigens, allergens and mitogens. Under the influence of mitogens, T-cells transform into blasts and divide in response to antigens that have entered the body, i.e. in response to mitogens, the number of T-cells increases. The functional activity of B-lymphocytes is judged by blast transformation in response to stimulation with lipopolysaccharide, and in response to stimulation with a latex mitogen - by cooperative processes between T- and B-lymphocytes. The proliferative response of lymphocytes to antigens gives an idea of the severity of specific sensitization of the body. States and diseases that lead to its change are similar to changes in blast transformation of lymphocytes without stimulation. The test is used for a comprehensive assessment of the patient's immune status.
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