Stimulated reaction of blast transformation of lymphocytes with mitogens
Last reviewed: 23.04.2024
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The values of the stimulated reaction of blastic transformation of lymphocytes in adults are normal: with PHA - 44-72%, with ConA - 40-75%.
The functional activity of T and B lymphocytes is judged by the reaction of blast transformation of lymphocytes with the use of mitogens - PHA, ConA, latex, lipopolysaccharides, etc.
Stimulated blast transformation of lymphocytes with mitogens (PHA, ConA) characterizes the functional ability of T-lymphocytes to transform and multiply under the influence of antigens, allergens and mitogens. Under the influence of mitogens, T cells turn into blasts and divide in response to antigens that enter the body, that is, an increase in the number of T cells occurs in response to mitogens. The functional activity of B-lymphocytes is judged by blast transformation in response to stimulation with lipopolysaccharide, and on mitogen stimulation of latex - on cooperative processes between T and B lymphocytes. Proliferative response of lymphocytes to antigens gives an idea of the severity of specific sensitization of the body. The states and diseases that lead to its change are similar to changes in blast transformation of lymphocytes without stimulation. The test is used for a comprehensive assessment of the patient's immune status.
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