Medical expert of the article
New publications
Renal non-sugar diabetes
Last reviewed: 04.07.2025

All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Causes renal non-sugar diabetes.
Renal diabetes insipidus develops due to the presence of a lack of sensitivity of epithelial cells of the distal tubules to arginine vasopressin (antidiuretic hormone), which is mainly due to a mutation of the V1-receptor gene of arginine vasopressin (X-linked form). In addition, the cause is a mutation of the gene encoding the water channel associated with the V2-receptor - aquaporin-2 (autosomal recessive form of inheritance).
Acquired renal diabetes insipidus develops with many diseases.
Symptoms renal non-sugar diabetes.
Primary renal diabetes insipidus is diagnosed in the first week of life.
Symptoms are typical: polyuria, repeated vomiting, convulsions; severe dehydration andhyponatremia often develop.
In older children, polyuria, nocturia, and polydipsia are detected.
Forms
Congenital renal diabetes insipidus
- Mutations in the genes of V1 receptors of antidiuretic hormone.
- Mutation of the aquaporin-2 gene.
Acquired renal diabetes insipidus
- Medicines:
- lithium preparations;
- amphotericin B.
- Nicotine.
- Alcohol.
- Chronic renal failure (especially as a result of tubulointerstitial nephritis and obstructive uropathy).
- Sickle cell anemia.
- Amyloidosis.
- Sjogren's disease and syndrome.
- Sarcoidosis.
- Hypercalcemia.
- Cystinosis.
What do need to examine?
How to examine?
Who to contact?
Treatment renal non-sugar diabetes.
Treatment involves the administration of hydrochlorothiazide, potassium supplements, and drinking plenty of fluids.
Limited sodium intake is also justified. Secondary renal diabetes insipidus can be completely eliminated by treating the underlying disease.
Drugs