Diseases of the genitourinary system

Shenlaine-Henoch disease and kidney damage

Illness of purpura Schonlein-Genocha is a systemic vasculitis that affects predominantly small vessels with the deposition of immune complexes that contain IgA in their wall, and is manifested by skin lesions in combination with gastrointestinal lesions, glomeruli of the kidneys and joints.

Microscopic polyangiitis

Microscopic polyangiitis - necrotizing vasculitis with or without minimal immune deposits, affecting small vessels (arterioles, capillaries, venules), less often the arteries of the middle caliber, with a predominance in the clinical picture of necrotizing glomerulonephritis and pulmonary capillaritis.

Treatment of kidney damage with Wegener's granulomatosis

Since the prognosis depends on the start of the treatment for Wegener's granulomatosis, the main principle of therapy is its early onset, even if there are no data of morphological and serological studies.

Diagnosis of kidney damage with Wegener's granulomatosis

In patients with Wegener's granulomatosis, a number of nonspecific laboratory changes are noted: an increase in ESR, neutrophilic leukocytosis, thrombocytosis, normochromic anemia, in a small percentage of cases eosinophilia.

Symptoms of kidney damage with Wegener's granulomatosis

The onset of the disease of Wegener's granulomatosis often proceeds in the form of an influenza-like syndrome, the development of which is associated with the circulation of pro-inflammatory cytokines, possibly produced as a result of a bacterial or viral infection preceding the prodromal period of the disease.

Causes and pathogenesis of kidney damage with Wegener's granulomatosis

The exact cause of Wegener's granulomatosis is not established. We assume a connection between the development of Wegener's granulomatosis and infection, which is indirectly confirmed by the facts of frequent onset and exacerbation of the disease in the winter-spring period, mainly after respiratory infections, which is associated with the ingestion of an antigen (possibly of viral or bacterial origin) through the respiratory tract.

Wegener's granulomatosis and kidney damage

Wegener's granulomatosis is a granulomatous inflammation of the respiratory tract with necrotic vasculitis of small and medium-sized vessels, combined with necrotizing glomerulonephritis.

Treatment of kidney damage with nodular periarteritis

The choice of the therapeutic regimen and doses of drugs is determined by clinical and laboratory signs of disease activity (fever, weight loss, disproteinemia, increased ESR), the severity and rate of progression of the lesions of internal organs (kidneys, nervous system, gastrointestinal tract), severity of arterial hypertension, active HBV replication .

Diagnosis of kidney damage with nodular periarteritis

Diagnosis of generalized nodular polyarteritis does not cause difficulties at the height of the disease, when there is a combination of renal damage with high arterial hypertension with violations of the gastrointestinal tract, heart, peripheral nervous system.

Pathogenesis of kidney damage with nodular periarteritis

Nodular polyarteritis is characterized by the development of segmental necrotizing vasculitis of middle and small caliber arteries. Features of vascular injury are the frequent involvement of all three layers of the vessel wall (panvasculitis)

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