List Analyzes – I
The half-life of immunoglobulin E is 3 days in the blood serum and 14 days on the membranes of mast cells and basophils. At repeated contact with the antigen (allergen), the interaction of reactive antibodies and antigens occurs on the surface of basophils and mast cells
Immunoglobulin A includes two types of specific proteins: serum and secretory. Immunoglobulin A in the blood serum is in the form of a monomer (90% IgA1), it is included in the fraction of β-globulins and accounts for up to 15% of Ig of blood serum.
In immunoglobulinopathy, an increase in the concentration of whey proteins, especially macroglobulins, or Ig, combined in immune complexes with clotting factors or other antigens, causes an increase in blood viscosity, which in turn leads to circulatory disturbances in small vessels and damage to their walls by immune complexes.
Immunoglobulinopathies, or gammopathies, combine a large group of pathological conditions characterized by polyclonal or monoclonal hypergammaglobulinemia. Immunoglobulins consist of two heavy (H) chains (molecular weight 50,000) and two light (L) chains (molecular weight 25,000).