List Analyzes – F
Factor XI - anti-hemophilic factor C - glycoprotein. The active form of this factor (XIa) is formed with the participation of factors XIIa, Fletcher and Fitzgerald. Form XIa activates factor IX. With the deficiency of factor XI in the coagulogram, the coagulation time of the blood and APTT is prolonged.
The plasma clotting factor VIII - anti-hemophilic globulin A - circulates in the blood in the form of a complex of three subunits, designated VIII-k (coagulating unit), VIII-Ar (the main antigen marker) and VIII-PV (von Willebrand factor bound to VIII-Ar ). It is believed that VIII-FV regulates the synthesis of the coagulation part of anti-hemophilic globulin (VIII-k) and participates in vascular-platelet hemostasis.
Factor VII (proconvertin, or convertinum) refers to α2-globulins and is synthesized in the liver with the participation of vitamin K. It is mainly involved in the formation of tissue prothrombinase and the transformation of prothrombin into thrombin. Its half-life is 4-6 hours (the shortest half-life among the coagulation factors).
Factor V (proaccelerin) is a protein fully synthesized in the liver. Unlike other factors of the prothrombin complex (II, VII and X), its activity does not depend on vitamin K. It is necessary for the formation of internal (blood) prothrombinase, activates factor X for the conversion of prothrombin to thrombin. In cases of factor V deficiency, the external and internal pathways for the formation of prothrombinase are disturbed to varying degrees.