Renin, which enters the blood from the juxtaglomerular apparatus of the kidneys, cleaves the angiotensinogen decapeptide angiotensin I, which, in turn, under the influence of the ACE, two amino acids are cleaved and angiotensin II is formed. Angiotensin II has two main functions: it stimulates the synthesis and secretion of aldosterone in the adrenal cortex and causes a reduction in peripheral blood vessels.