^

Health

A
A
A

Lymphomatoid papulosis: causes, symptoms, diagnosis, treatment

 
, medical expert
Last reviewed: 23.04.2024
 
Fact-checked
х

All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.

We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.

If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.

The causes and pathogenesis of papulosis of the lymphomatoid remain unknown. Many scientists consider papulosis lymphomatoid as a nodular form of skin lymphoma with a slow tumor progression. The disease is observed in young and middle-aged people, more often in men.

Symptoms of Papulosis of Lymphoma. Clinically, the disease resembles a drop-shaped parapsoriasis, and histologically - a true lymphoma. Foci of lesion are located mainly on the trunk and extremities, as well as on the face, scalp, palms or genitals. The most characteristic are cyanotic-pink papules or papulesvezicles with scales, crusts or areas of necrosis on the surface. The cycle of development of individual elements, as a rule, is 4-6 weeks, sometimes ends with the formation of atrophic scars; may be observed gillerkeraticheskie plaques, disposed nodes and bullous rashes.

Lymphoma papulosis usually has a benign course from 6 months to 20 years.

Histopathology. In the epidermis, minor parakeratosis, acanthosis, spongiosis, and sometimes exocytosis of mononuclear cells are revealed. In the superficial layers of the dermis - infiltrates from T-lymphocytes with pronounced epidermotropism. In the middle and deep layers of the dermis, perivascular and periglundular infiltrates of lymphocytes with an admixture of atypical cells resembling convoluted T-lymphoblasts or immunoblasts can be observed. There may be indistinct signs of vasculitis.

Differential diagnosis must be carried out first with drop-like parapsoriasis, papulonectrotic vasculitis, and papulonecrotic tuberculosis. In this case, histological research is of decisive importance.

Treatment of papulosis lymphoma. Assign corticosteroids, large doses of tetracycline, PUVA-therapy. A positive effect of methotrexate is described.

trusted-source[1], [2], [3], [4], [5], [6]

What do need to examine?

You are reporting a typo in the following text:
Simply click the "Send typo report" button to complete the report. You can also include a comment.