Hypercholesterolemia

The pathological abnormality that will be considered in this article is not a disease, but a deviation from the norm, a serious deviation. Hypercholesterolemia initially does not seem very dangerous, you'll think about a high cholesterol in the plasma. But with prolonged observation of such values, the situation is only aggravated, leading to severe pathologies.

ICD-10 code

As already stated, the malaise in question is not a disease, but only a deviation. But the seriousness of the changes that they entail are confirmed by the serious attitude of physicians towards this problem. After all, hypercholesterolemia has its own code in the international classification of diseases. According to the ICD 10 - pure hypercholesterolemia - is coded as E78.0 and is a point in the category of ailments affecting lipoprotein metabolism (the code of the subsection is E78).

Causes of hypercholesterolemia

A certain pathological syndrome, called hypercholesterolemia, is a harbinger, talking about the development of the defeat of the blood vessels of the entire circulatory system of the human body. Such changes affect the nutrition of the heart and other internal organs, capillaries of the brain, upper and lower extremities. This failure in work is a harbinger of developing atherosclerosis, a complication that can affect any part of the human body, which is the impetus for the development of other, more serious diseases.

The causes of hypercholesterolemia are different, and have a diverse nature.

• This deviation a person is able to receive by inheritance, with birth. The source of the altered gene is able to become both one and both parents. Defective changes in the gene are associated with a violation of information responsible for the production of cholesterol.
• The development of violations is practically not preventable if a person abuses food containing a large number of animal fats.
  • Transient manifestations of the disease in question can be observed in the case when the day before the patient was eating a lot of fatty foods.
  • A constant manifestation can be observed, when the high fat content of the products is the norm for the patient's diet.
• The source of failure in the normal functioning of the organism leading to the clinical picture in question is the disease:
  • Hypothyroidism is a condition that develops against a background of a lack of hormones in the thyroid gland, obtained due to an operative intervention or a flowing inflammatory process.
  • Diabetes mellitus is a disease in which the ability of glucose to penetrate into cellular structures decreases. Sugar values above 6 mmol / l at normal rates of 3.3-5.5 mmol / l.
  • Obstructive changes affecting the functioning of the liver. This pathology is caused by a deterioration in the outflow of bile from the liver in which it is produced. For example, it can be cholelithiasis.
• Such a change in the body can also be caused by long-term use of certain medications. These include immunosuppressants, diuretics, beta-blockers and some others.
• Modifiable causes of the development of pathological disorders are those that are corrected when patients are reconsidered their way of life.
  • Conducting a sedentary lifestyle, expressed in hypodynamia.
  • Food.
  • The presence of bad habits: the abuse of alcoholic beverages, drugs, consumption of nicotine.
• Hypertensive disease - persistent high blood pressure.
• The development of this pathology is influenced by non-modifiable factors:
  • The predominant predisposition is men over 45 years of age.
  • It is aggravated by a family history, if in the family of the patient the next male relatives (earlier than 55 years) already diagnosed with early atherosclerosis.
• In the patient's anamnesis, there is a myocardial infarction, the consequences of which are the blocking of blood supply to a certain area of the heart muscle, after which it dies.
• An ischemic stroke that provokes necrotic processes affecting the brain area.

[1], [2], [3], [4], [5]

Biochemical disorders

In order to understand the causes and consequences of the emergence and development of a particular ailment, it is necessary to understand as best as possible the mechanism of the course of changes that are different from the norm. Biochemistry of hypercholesterolemia is a disorder affecting the procedure for lipid metabolism.

In the human body with food products fatty structures of different classification belong: complex lipid formations, glycerol esters, free cholesterol, triacylglycerides and others.

After the food has entered the digestive tract, the body begins to process it. The food product "decomposes" into components, each of which is processed by a specific enzyme. There is also a splitting of fats. Each type of fat structure is treated with its enzyme. For example, triacylglycerides under the action of biocatalysts of the liver and pancreas (bile and pancreatic acid) are split into smaller compounds. A similar process occurs with other lipids.

Free cholesterol is adsorbed unchanged, whereas its derivatives having a more complex structure are primarily subjected to modification. Only after this occurs their adsorption by enterocytes, cells that make up the mucosa of the small intestine.

In these cells, fats undergo further modification, transforming into forms suitable for transportation, which have their name - chylomicra. They are represented by a fat droplet of microscopic size, which has a coating in the form of a thin protective shell of phospholipids and active proteins.

In this form, the former fats enter the lymphatic system through the enterocytic barrier, and through it further into the peripheral blood vessels.

It should be noted that without the support of other components, chylomicrons can not penetrate into the necessary systems and organs of the human body independently. Such support is found in blood lipoproteins (complete compounds of lipids and protein formations). Such compounds allow the chylomicrons to "get" to the desired organ without dissolving in the blood fluid.

It is the lipoproteins that play the leading role in the development of a pathology called hyperlipidemia. This symptom begins to form after a disturbance occurs in the normal operation of lipoproteins.

There is a classification of these enzyme formations depending on their density. It is light and ultra-light lipoproteins that are the cause of the development of the disease. They are produced by the liver, and then transported to the enterocytes, in which their joining to the chylomicrons takes place. In this bundle, this tandem enters the tissue interlayers.

Low-density lipoproteins (LDL) are the "transporting organ" for cholesterol, delivering it to organs and systems.

The functional feature of high-density lipoproteins (HDL) is to remove excess cholesterol plaques from cellular structures, which elevates them to the rank of the main guardian of an organism endowed with anti-atherogenic characteristics.

That is, low-density lipoproteins are transport, and high-density lipoproteins are protection.

Proceeding from this, it can be understood that hypercholesterolemia begins to develop when there is a disruption in the normal functioning of low density lipoproteins, which for some reason cease to distribute the chylomicrons to the necessary organs.

[6], [7], [8], [9], [10], [11]

Symptoms of hypercholesterolemia

One of the main signs of the appearance of the deviations in question is the appearance in the patient's body of "deposits". There are also symptoms of hypercholesterolemia, which are manifested by the appearance of such factors:

• Areas where the presence of tendons are anatomically justified (the Achilles joint and extensor joints of the phalanges of the upper and lower extremities become especially affected), puffiness and the appearance of hummocky growths - xanth - can be observed. This, in fact, pockets with cholesterol accumulations.
• Very similar neoplasms can be observed in the lower and upper eyelids, and the inner eye corners are also affected. The spots of orange and yellowish shade - xanthelasm - begin to appear.
• If you look at the cornea of the patient's eye, you can see a strip of gray on the rim.
• Primarily, it is possible to observe secondary symptoms of abnormality, which are caused by more serious lesions of the capillary system leading to the development of atherosclerosis, strokes, heart attacks and so on.

The most recognizable signs of the pathology under consideration are the symptoms that appear as indicators of the presence of atherosclerotic changes in a person's history. The spectrum of such manifestations is quite wide: from the defeat of the capillaries of the brain, to the circulatory system, which supplies the upper and lower extremities. Depending on the place of primary localization, some individual features of the manifestation will be observed.

It should also be noted that the emergence of significant symptoms suggests that the pathological changes are neglected, because the real clinic becomes noticeable only when the level of cholesterol in the blood serum reaches persistent critical values. Before the onset of such a moment, the bright pathological symptomatology may not be noticeable.

Hypercholesterolemia and atherosclerosis

Atherosclerosis is a disease attributed to chronic diseases. The basis of its inception is determined by violations that affect lipid and protein metabolism in the patient's body. In physical manifestation, these changes are expressed by loss of elastic vessels, they become fragile. The second significant indicator of the presence of atherosclerosis is the proliferation of connective cell tissues.

High cholesterol, in many cases, is the precursor of atherosclerosis. Therefore, doctors paid special attention to this fact. After the study, the results showed that in half of patients diagnosed with atherosclerosis the cholesterol values remained within normal limits, while the second half had higher figures.

Analyzing the results of monitoring, experts note that hypercholesterolemia and atherosclerosis go hand in hand when the development of pathology occurs quickly enough.

Different sources give such figures of the frequency of joint manifestation of these two diseases - from 60 to 70%. These data were obtained not only by studying the clinical picture of the disease, but also its comparability with the pathoanatomical examination of the state of the walls of the vessels. Comparative analysis showed that if a person had problems with excessive cholesterol during his life, his posthumous histology showed progressive development of atherosclerotic characteristics, in the form of newly formed cholesterol deposits inside the capillary passages.

If the histology showed regression of atherosclerotic changes, the in vivo medical chart showed a norm or, conversely, a lowered cholesterol index.

Observations showed that high cholesterol together with atherosclerosis is more often observed in their early manifestation, when the patient is not yet 55 years of age. Over time, the clinical picture of the disease changes, "folding" with various complications.

Hypercholesterolemia in children

This disease can be diagnosed in a baby immediately after birth. Such pathology can persecute a person throughout life. The swelling of Achilles succulents in small patients should alert a qualified physician for family pathology.

Hyperlipidemia in children is usually indicated by an increase in cholesterol in the blood from 8.0 to 12.0 mmol / l. This indicator can be detected even in the first hours of life.

Classification of hypercholesterolemia

Having different sources of manifestation, pathology is divided into different groups. The classification of hypercholesterolemia is a few points:

Primary - pathological changes that are inherent in nature.

• To a secondary pathology carry, provoking factor which is one of the diseases. That is, a person was born healthy by the factor under consideration, but acquired it in the process of life.
• The alimentary form of the disease is a sublevel of the secondary, but it is somewhat withdrawn separately due to the fact that the impetus to the progress of the disease under consideration is not the specific disease, but the way of life that man leads-his habits. To such it is possible to carry:
  • Smoking.
  • Abuse of alcoholic beverages.
  • Addiction to fatty foods.
  • "Love" for fast food products, food products, which include all sorts of chemical additives: stabilizers, dyes and so on.
  • Keeping a sedentary lifestyle.
  • And other.

Frederickson made the most detailed and more extensive classification. This is a common distinction of pathology, depending on the reasons that provoked it. Although the specificity of differences in the failure in the processes of lipid metabolism is fully understood only by a qualified physician.

[12], [13], [14], [15], [16]

Types of hypercholesterolemia

Classification of the disease according to Fredrickson suggests a breakdown of the problem under consideration by etiology, determining its type membership.

There are the following types of hypercholesterolemia:

• Pathology type I - the primary, hereditary. Rarely occurring. Progresses with a deficiency of lipoprotein lipase, as well as in the case of a disruption in the structure of the activating protein lipoprotein lipase - apoC2. Symptomatic is defined as a high concentration of chylomicron. The frequency of development is 0.1%.
• Pathology type II - polygenic, or congenital. Shares:
  • IIa type - lack of low density lipoprotein lipases. It can be the result of an improper diet, or the innate factor has worked. The frequency of manifestation is 0.2%.
  • IId type - decrease in the level of lipoprotein lipases of low receptor density and growth of apoB. The frequency of diagnosis is about 10%.
• Pathology type III - hereditary dis-β-lipoproteinemia. Defect apoE. The frequency of development is 0.02%.
• Pathology type IV - endogenous. Increase in the intensity of the formation of triglycerides, as well as acetyl-coenzyme A and apoB-100. The frequency of development is 1.0%.
• V type pathology is a hereditary etiology. Increased triglyceride formation and decreased lipoprotein lipase.

Primary hypercholesterolemia

To understand the difference, it is necessary to get acquainted with at least the most frequently encountered sources of changes leading to the disease in question. The term primary hyperlipidemia was violated, the main causes of which is:

• Violation of the structural structure of the protein of lipoproteins, which leads to a malfunction of the functional consistency of low density lipoproteins, which lose the ability to attach to tissue cells, and therefore the chylomicrons transported by them with cholesterol can not enter the cell.
• There is a depressing process of the development of transport enzymes, which are responsible for the seizure by lipoproteins of chylomicrons, for further transfer through the systems of the body. This failure leads to the fact that there is a shortage of cholesterol in one place and there is a cumulation where they do not need surplus.
• Structural changes affecting the tissue cell itself, leading to loss of its contact with lipoproteins. Here we get a situation similar to point 1, but with the difference that the reason for the unsuccessful interaction does not come from the enzyme or representatives of lipoproteins, but on the other hand from the "landing" cell.

Secondary hypercholesterolemia

Another, most often diagnosed by a variety of causes, is secondary hypercholesterolemia, which was not inherited, but acquired in the course of its life. The cause of this clinical picture is alcohol, if the patient does not know the measures of its use, sedentary lifestyle and many other factors directly dependent on the person.

To provoke the problem are capable of violations occurring in the endocrine system, pathological changes affecting the work of internal organs. After all, the body is a single mechanism and the malfunction of one system, invariably entails other changes.

Hyperlipidemia begins to progress if changes have affected the transportation of fatty structures from enterocytes to cells, or impaired lipoprotein synthesis, or the oppression of their utilization has occurred.

Hereditary hypercholesterolemia

Autosomal dominant pathology related to the diseases of the monogenic group, that is, determined by only one gene. Violation affecting the failure of low density lipoids. At the same time, the disorder occurs at the gene level and is inherited, being congenital.

A person with such a defective gene can get both from one parent and from both if they have an anamnesis in their illness.

The risk factors for high cholesterol include:

• Family history, weighed down by this deviation.
• Diagnosis of early age heart attacks, both in the patient himself and his relatives.
• A large indicator of low-density lipoproteins at least one of the parents. The burden of the anamnesis can consist in the stability of the pathogenic situation towards drug therapy.

Cholesterol is a natural enzymatic component of many biochemical processes and a necessary element of the cell membrane. Cholesterol deficiency leads to a malfunction in the synthesis of various hormones. The greater their quantity enters the human body with animal fat, some amount is produced by the liver.

Excessively cholesterol can be divided into one that promotes the development of atherosclerosis - low density lipoprotein (LDL), and one that keeps its quantity under control, on the contrary, protecting against the nucleation and progression of the disease is high-density lipoproteins (HDL). It is high-density lipoproteins that can reduce the likelihood of cardiovascular abnormalities.

Family hypercholesterolemia

A malaise of a family type is attributed to hereditary diseases, which are one of its subspecies. To date, it is responsible for 10% of defects affecting coronary arteries, which are diagnosed in still young people under 55 years of age. The source of such disorders is the mutated gene. This pathology occurs quite often, especially in families living in contaminated industrial megacities. 200-300 healthy genes have one mutated.

Familial hypercholesterolemia according to Fredrickson classification refers to type 2. The essence of this ailment boils down to the fact that because of a malfunction in genetics, lipoproteins lose the ability to communicate with cholesterol and transport it to the right organ. Parallel to this, there is an increase in the number of synthesized cholesterol plaques, which is also a violation.

And as a result - plaques begin to be cumulated in places where they should not be, which leads to the development of cardiovascular diseases, coronary disorders. This is one of the reasons for diagnosing "early" heart attacks.

[17], [18], [19], [20]

Family homozygous hypercholesterolemia

If two mutated allelic lipoprotein gene of low density are detected during diagnosis, and this ailment belongs to the hereditary, then the doctors state the hereditary disease denoted by the term.

This mutation provokes a rapid disruption of lipid decomposition, as well as a complete absence of receptors. How regrettable it sounds, but the mutational changes of such a plan are often enough, one clinical manifestation per one hundred thousand people.

The frequency of the pathology encountered is also divided according to the type of "destruction":

• In patients with complete absence of receptors, this activity shows only 2% of normal work, and the level of low-density lipoproteins increases dramatically.
• With a defect in the receptors, the activity of their work falls within an interval of 2-25% of the norm, the number of low-density lipoproteins is slightly below normal.

[21], [22], [23], [24], [25], [26],

Heterozygous familial hypercholesterolemia

One of the most common varieties of the disease in question, the frequency of which is diagnosed as one clinical picture in five hundred healthy cases.

The essence of pathology is a mutation of one gene, leading to its defective lesion. Symptomatic of this manifestation of the disease are:

• Increase in the level of total cholesterol.
• Increasing the amount of LDL.
• The level of triglycerides is close to normal.
• Diagnosis of early heart disease.
• Weighed down a family anamnesis.
• The presence of tendon xanthomas, although their absence in the body is not a sign of health. This is especially true for the child's body. These samples are taken in the field of Achilles tendons. Visually this situation is manifested in puffiness and tuberous formations. Another area of the appearance of thickening and tubercles is the back of the palms of the upper limbs and the flexor tendons of the phalanges.

Diagnosis significantly increases the likelihood of the patient developing cardiovascular diseases (for example, ischemic heart disease) at a young age.

Such a clinical picture should be recognized in infancy, it will allow to control the indicator parameter in a direct way, not allowing pathological changes in the body.

Pure hypercholesterolemia

It is caused by an increase in the quantitative component of cholesterol in the blood. Such a diagnosis is made to the patient if this criterion is determined by a figure of more than 5.18 mmol / l. This is a pathology, which is the dominant symptom of atherosclerosis development.

Medical statistics say that about 120 million of the world's population have serum cholesterol about 5.18 mmol / L and higher, and 60 million this figure is already determined by the figure of 6.22 mmol / L and more.

Diagnosis of hypercholesterolemia

If the doctor, by some indication, begins to suspect his patient of the disease in question, he appoints a more detailed directional examination, since it is impossible to put a correct diagnosis visually. Diagnostics includes several mandatory items

1. Analysis of patient complaints.
2. Clarification of the limitation period for the appearance of xanthelasm, xanthoma, lipoid corneal arc.
3. Collection of anamnesis of the patient. Presence of the patient or his close blood relatives of such diseases as a suffered heart attack or stroke. Do any of the relatives have the disease in question.
4. A physical examination is mandatory.
5. The main diagnostic index of the disease is the result of the analysis of the specific lipid profile of the blood plasma - the lipidogram. On its basis, the determination of the number of different lipids (cholesterol, triglycerides, high and low density lipoproteins) is carried out. Immediately, they are the criterion for the presence or absence of pathological changes. The coefficient of atherogenicity is determined.
6. A general analysis of urine and blood is prescribed. Inflammations, other malfunctions and abnormalities are detected.
7. Obligatory and biochemical analysis of plasma, which allows you to determine the quantitative parameters of protein, uric acid, creatinine, sugar and other blood components.
8. Immunological study of blood allows you to determine the presence of antibodies to chlamydia and cytomegalovirus, as well as the level of C-reactive protein.
9. Modern medical equipment makes it possible to carry out genetic studies to identify a defective gene that carries information related to the metabolism of lipids. This gene is responsible for the hereditary form of the development of the disease.
10. Measurement of blood pressure.

[27], [28], [29], [30], [31]

Nutrition and diet for hypercholesterolemia

This is a very important "brick" in the activities that are used to stop the problem that has arisen. Having reconsidered their predilections, the patient can significantly change the situation for the better by significantly reducing the amount of cholesterol plaques in the blood.

If the disease does not go too far. Sometimes it is enough to remove "bad" products from your diet and this insignificant step will allow to keep this indicator at the values allowed by the norm.

The first thing that a patient needs to do is remove the fatty foods of animal origin from his diet. They can be replaced by plant analogues. Thanks to this, it is possible to significantly reduce the amount of excessive cholesterol plaques. Fatty types of fish and fish oil, on the contrary, are desirable in the nutrition of such a patient.

Refuse meat and meat products should not be, but they should not be fat. A more serious restriction concerns by-products (liver, brain structure, kidneys). Smoked meat and eggs (yolks) should be minimized. The cholesterol of such products is "off scale".

The diet for hypercholesterolemia resolves the consumption of low-fat dairy products (no more than 1-2%), and fermented milk products are welcomed.

It is necessary to remove from your diet butter, fast food products, baking. Buying bakery products, you need to monitor that they were from bran, wholemeal.

The patient's diet should include all kinds of cereals, cooked on water or low-fat milk. Well cleanses the vessels of green tea and nuts. But a lot of eating nuts is not worth it, because this is a high-calorie product.

How strange it sounds, but in moderate doses, alcohol contributes to inhibiting the development of atherosclerosis. But the "therapeutic dosage" should not be higher than the daily rate corresponding to 20 ml of pure alcohol, which roughly corresponds to 40 ml of vodka, 150 ml of wine, 330 ml of beer. Such dosages are suitable for the body of a man, for women these figures should be reduced in half. It's about a quality product, not a surrogate. At the same time, we should not forget that if there is a cardiovascular pathology in an anamnesis, alcohol is contraindicated.

It is worth to get rid of coffee. Studies have shown that if you abandon this drink, the cholesterol level in the body is reduced by 17%.

In the diet of such a patient must necessarily be the required amount of legumes, fruits and vegetables, so that the body does not feel a shortage of vitamins and minerals.

If a person loves seafood, then scallops, mussels and other seafood can significantly diversify the patient's diet.

For such patients, all meals should be steamed, boiled or baked.

Menu diet for hypercholesterolemia

As the recommendations show, the diet for this disease is simple and quite diverse. Therefore, there are no great difficulties in making up the menu for hypercholesterolemia. And if the patient loves meat, let it enter in its dish, you just have to check that the product was not fat and prepared by one of the permitted methods.

The menu of one day for such a patient can, for example, be as follows:

• Breakfast: casserole - 150 g., Green tea.
• Lunch: orange.
• Lunch: lean borsch - 200 g., Fish baked with vegetables - 150 g., Apple juice - 200 ml.
• Afternoon snack: broth rose hips - 200 ml., Apple.
• Dinner: pearl barley on the water with boiled meat - 150 g., Salad from fresh carrots - 50 g., Tea with milk.
• Before going to bed - a glass of yogurt.

The total daily amount of bread is 120 g.

Treatment of hypercholesterolemia

The therapy of the pathology in question includes both medication and non-pharmacological techniques. Treatment of hypercholesterolemia of non-pharmacological orientation includes several recommendations:

• Weight control.
• Moderate physical activity, individually calculated for each patient. Physiotherapy exercises, morning jogging, swimming pool and other components of outdoor activities.
• Balancing the diet with the observance of all dietary requirements for the ailment in question.
• Rejection of bad habits. Especially it concerns alcohol and nicotine.

If the above methods are "not enough" to maintain the cholesterol level within the norm, the doctor prescribes medication.

Drugs for hypercholesterolemia

Primarily, after analyzing the clinical picture of the disease, the attending doctor paints a diet for such a patient, gives recommendations on lifestyle changes, prescribes therapeutic physical activities. And if such a complex of changes does not lead to the desired result, the specialist has to resort to the help of pharmacology.

Predominantly, patients with this diagnosis are prescribed statins (eg, atorvastatin), which effectively reduce cholesterol in the patient by inhibiting the enzyme that activates its production.

Atorvastatin is administered orally at any time of the day, in conjunction with meals. The starting daily dosage is from 10 mg to 80 mg. The corresponding figure is assigned by the doctor individually for each patient. During the treatment, after two to four weeks, it is necessary to monitor the cholesterol in the patient's blood, thus adjusting the dosage accordingly.

In parallel with statins, fibratam, lowering the level of lipids and triglycerides with a simultaneous increase in the concentration of high-density lipoproteins, as well as sequestrants of bile acids, which enhance the process of splitting of excess cholesterol, can be prescribed.

The specialist can enter into the protocol of treatment of omega-3 polyunsaturated fatty acids, regulating the number of triglycerides, as well as favorably affecting the functioning of the heart. Triglycerides are introduced, for example, ezetimibe, which blocks the absorption of small intestine by cholesterol.

[32], [33], [34], [35], [36]

Treatment of hypercholesterolemia with alternative agents

To cure the problem, treatment is often used by alternative means. Such recipes are numerous. Here are some:

• Grated seeds of milk thistle are taken on a teaspoon with food.
• The infusion of celandine, which is prepared from a gram of dry plant and a glass of boiling water, showed itself well. After the infusion, drain the liquid and take it over a dessert spoon three times throughout the day.

Prevention of hypercholesterolemia

Every person knows that it is easier to maintain your body at a "healthy" level than to apply a lot of effort to get rid of the disease and restore your former health. Prevention of hypercholesterolemia is not excessively complicated, but adhering to the above recommendations, you can significantly protect your body from violations that invariably occur against a background of high cholesterol.

• It is necessary to monitor your weight.
• Avoid high-calorie food.
• Bread, fatty, smoked and peppery foods from your diet.
• Increase the volume of fruits and vegetables rich in vitamins, minerals and fiber.
• Remove bad habits: alcohol, nicotine.
• Doing sports with individually matched loads.
• Avoid stress and great emotional stress.
• Periodic control of the amount of cholesterol plaques in the blood is necessary.
• Control of blood pressure.
• Obligatory full treatment of diagnosed diseases that can provoke high cholesterol.
• When the first pathological signs appear, seek the advice of a specialist and, if necessary, undergo medical treatment.

Hypercholesterolemia - this term is used to designate doctors not as a disease, but as a symptom capable of causing serious enough disturbances in the patient's body. Therefore, even an insignificant violation of its level in the blood should not be ignored. In the early stages of development, this pathology can easily be kept in normal by a corrected diet and recommended diet. If this stage of therapy has been ignored, then a person risks further to get more complex and sometimes irreversible diseases, for example, atherosclerosis, heart attack, stroke and others. To save your health in a timely appeal to a doctor is possible only by the person himself. Therefore, be more attentive to your body and do not brush off his signals for help. After all, eaten a piece of fatty meat is not worth the spoiled quality of the rest of life!