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Wagner's disease: causes, symptoms, diagnosis, treatment
Last reviewed: 07.07.2025
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Wagner's disease also refers to vitreoretinal dystrophies with an autosomal dominant type of inheritance. The gene responsible for the development of Wagner's disease is localized on the long arm of chromosome 5.
Symptoms of Wagner's disease
The main clinical symptoms of Wagner's disease are the presence of myopia, often of a high degree, and preretinal membranes with an "optically empty" vitreous body in combination with retinoschisis, retinal dystrophy and pigment epithelium. Already at the age of 10-20 years, opacities of the lens are detected, which progress rapidly; secondary glaucoma and retinal detachment are often observed.
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Diagnosis of Wagner's disease
The diagnosis is established based on family history, results of biomicro- and ophthalmoscopy, perimetry, electroretinography and fluorescent angiography. Perimetry reveals concentric narrowing of the visual field, less often - ring-shaped scotoma. ERG is sharply subnormal.
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