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Pulmonary eosinophilia with systemic manifestations: causes, symptoms, diagnosis, treatment

Alexey Kryvenko, medical expert
Last reviewed: 04.07.2025

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This group of diseases is characterized by pronounced eosinophilia in the peripheral blood, pulmonary infiltrates and involvement of many organs and systems in the pathological process.

Allergic eosinophilic granulomatous angiitis

In allergic eosinophilic granulomatous angiitis (Churg-Strauss syndrome), small and medium-sized vessels are affected, which is combined with bronchial asthma, pulmonary infiltrates, high eosinophilia of the peripheral blood, systemic damage to organs (gastrointestinal tract, kidneys, cardiovascular system, musculoskeletal system, nervous system, skin).

Hypereosinophilic myeloproliferative syndrome

The causes of the disease are unknown. It is characterized by damage to the vascular endothelium, endocardial fibrosis, and bone marrow hyperplasia with a high content of eosinophils.

The main clinical manifestations of the disease are:

development of progressive restrictive heart failure (according to echocardiography data - the heart is small in size, the heart cavities are sharply reduced due to the development of pronounced fibroplastic processes);
high frequency of thromboembolic complications, especially in the pulmonary artery system;
lung damage in the form of infiltrates (they are easily detected radiologically);
fever, arthralgia, myalgia, polymorphic skin rashes, lymphadenopathy;
hepatosplenomegaly;
kidney damage in the form of glomerulonephritis (proteinuria, hematuria);
CNS damage (Gordon's symptom);
high blood eosinophilia;
bone marrow hyperplasia with a high content of eosinophils (detected by myelogram analysis).

The prognosis of the disease is unfavorable. Patients quickly die from progressive heart failure and thromboembolic complications.

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