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Ischemic hepatitis: causes, symptoms, diagnosis, treatment

 
, medical expert
Last reviewed: 05.07.2025
 
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Ischemic hepatitis (acute liver infarction; hypoxic hepatitis; shock liver) is a diffuse liver lesion resulting from generalized liver ischemia of any etiology.

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What causes ischemic hepatitis?

The most common causes of ischemic hepatitis are decreased cardiac output, systemic hypotension, and systemic hypoxia. Centrizonal necrosis occurs without liver inflammation. High aminotransferase levels are the only indication of hepatitis.

Where does it hurt?

Diagnosis of ischemic hepatitis

Ischemic hepatitis may be suspected in patients with systemic hypoperfusion. Within a few hours, serum aminotransferase levels increase (almost 200-fold) along with LDH. Serum bilirubin increases only 4-fold. If perfusion is restored, aminotransferase levels decrease within 1-2 weeks.

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What do need to examine?

Treatment of ischemic hepatitis

Treatment is aimed at eliminating the underlying cause. In most cases, liver function is fully restored. In patients with liver cirrhosis, fulminant liver failure may develop.

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