Hemophagocytic syndrome is more often primary - that is, hereditary type as a result of genetic disturbance in the work of macrophages.
Secondary hemophagocytic syndrome is also called acquired: it is associated with various infectious pathologies, tumor processes, autoimmune diseases, congenital metabolic disorders.
In the classical version of the hereditary type of hemophagocytic syndrome, children are often placed for treatment in the intensive care unit or ICU in infectious hospitals, diagnosing septic complications or intrauterine generalized infection. Direct diagnosis of hemophagocytic syndrome is often established after a fatal outcome.
However, common at first glance, infectious diseases of viral or microbial origin can cause such a complication as a life-threatening hemophagocytic syndrome.
Hemophagocytic syndrome in adults is almost always secondary in most cases: most often pathology develops against the background of lymphoproliferative diseases and chronic VEB infections.
Hemophagocytic syndrome in children can be both primary and secondary - due to the transferred infectious diseases (chicken pox, meningoencephalitis, etc.).