Grover's transient acantholytic dermatosis: causes, symptoms, diagnosis, treatment

Grozer's transient acantholytic dermatosis was first described in 1970 by RW Grower. In the scientific literature it is called Grover's disease.

The causes and pathogenesis of transient acantholytic Grover dermatosis have not been fully studied. However, most authors express the opinion that UV-radiation plays a decisive role in the onset of this disease. The disease most often occurs in people with a nervous disorder, predisposed to allergic reactions, and especially sensitive to ultraviolet rays.

Symptoms of transient acantholytic dermatosis Grover. The disease is observed mainly in men of middle age and senile age. In the unchanged or edematic erythematous, and sometimes, on the healthy skin, bright red nodules of a firm consistence appear. On the surface of the nodules, it is possible to observe scales, crusts or vesicles, similar to the papule-vesicle with trophyus. The presence of pruritus is considered a characteristic symptom of the disease. The rash is most often located on the neck. Shoulders, chest and lumbar parts of the body, mainly gives a frequent relapse in the summer months.

Histopathology. The presence of acantholytic foci in the epidermis is considered a pagognomonic symptom characteristic of this disease. However, histopathological changes on the skin resemble pemphigus, Darya's disease and Hailey-Hailey's disease.

Differential diagnosis. The disease should be distinguished from Darya's disease, Haley-Haley, pemphigus, and also from pruritus of adults.

Treatment of transient acantholytic dermatosis Grover. With a mild course of the disease, vitamins A, antibiotics and corticosteroid ointments are recommended. If these procedures do not help or the disease is severe, then corticosteroids are prescribed (daily dose is 10-15 mg of prednisolone) or aromatic retinoids.