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Gottron's carcinoid papillomatosis of the skin
Last reviewed: 04.07.2025
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Gottron's cutaneous carcinoid papillomatosis is a rare disease first described by Gottron in 1932.
Causes and pathogenesis
The causes and pathogenesis of Gottron's carcinoid papillomatosis of the skin have not been sufficiently studied. Chronic long-term diseases and mechanical injuries are considered to be of great importance in the development of the disease.
Histopathology
Histologically, acanthosis is observed with overgrown epithelial outgrowths penetrating deep into the dermis. When the connection of the strands with the epidermis is lost, nests of epithelial cells are found in the dermis.
Symptoms of Gottron's cutaneous carcinoid papillomatosis
The disease is more common in men than in women. Carcinoid papillomatosis often develops on the site of a long-standing dermatosis (eczema, lichen planus, ichthyosis, lupus tuberculosis of the skin, etc.) or on scars. Symmetrical (less often - one-sided) tumor-like lesions on the skin of the lower extremities are typical, which are sharply demarcated from the surrounding healthy skin, protrude above its level, and have a doughy consistency. The surface of the lesion resembles cauliflower, since there are vegetations on its surface, which are separated from each other by grooves, where there is a sticky discharge with an unpleasant odor and horny masses of a yellowish-whitish color.
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Differential diagnosis
The disease is differentiated from chronic vegetative pyoderma, warty tuberculosis of the skin, highly differentiated squamous cell carcinoma of the skin, and chromomycosis.
Treatment of Gottron's carcinoid papillomatosis of the skin
Broad-spectrum antibiotics, vasodilators, vitamin preparations, and cytostatics are prescribed. For local therapy, lotions of furacilin solutions, potassium permanganate (1:10000), and dressings soaked in hypertonic sodium chloride solution are recommended. After eliminating the secondary infection, warty lesions are removed. Cryo- or laser destruction is performed for this purpose.