Cancer of the sebaceous glands: causes, symptoms, diagnosis, treatment

Cancer of the sebaceous glands is extremely rare, mostly on the scalp and face. Clinically it is small, ulcerating, locally destructive, often metastasizing tumors. It is formed on the basis of developmental anomalies (naevus sebaceus), and more often from the analogues of the sebaceous glands in the submucosal tissue of the lower eyelid - meibomian glands.

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Pathomorphology of the cancer of the sebaceous glands

The tumor is located in the deep sections of the dermis, extends to the hypodermis, with the epidermis is not connected. Constructed from the lobules of various sizes and shapes, consisting of small cells located on the periphery of the lobules, and larger ones in their central parts. All cells with the phenomena of vacuolization contain, although lean, lipid material. Lipids are found in undifferentiated cells and in the region of pseudocysts. Sometimes there may be incomplete keratinization, as well as the absence of a lobular structure.

Differentiate this tumor from the epithelium of the sebaceous glands by the presence in the last ducts and the absence of cell polymorphism. From basaloma with sebaceous differentiation, this tumor is distinguished by a much smaller number of basaloid cells. In cancer of the sebaceous glands, accompanied by decay with the formation of cysts, it is necessary to assume acantholytic spinaloma or cancer of sweat glands with strong vacuolization of anaplastic cell elements.