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Berylliosis of the skin
Last reviewed: 07.07.2025
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Berylliosis is a systemic occupational disease with predominant damage to the respiratory system, which is based on the formation of typical immune granulomas from the introduction of metals. Beryllium granulomas in the skin develop as a result of beryllium entering through damaged skin, less often - hematogenously. Clinically, the lesions look like small or large-nodular, bluish or yellowish-red formations, similar to those in sarcoidosis. Ulceration may occur. Skin tests with beryllium are usually sharply positive.
[ Pathologists of berylliosis
Skin granulomas in systemic berylliosis are indistinguishable from granulomas in sarcoidosis, since they are almost not subject to necrosis. Beryllium particles are usually not visible in histological sections, but they are detected by spectrography.
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