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Acrokeratosis verruciformis Gopf: causes, symptoms, diagnosis, treatment
Last reviewed: 07.07.2025

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Acrokeratosis verruciformis Hopf is a genodermatosis with an autosomal dominant type of inheritance. It sometimes occurs in combination with Darier's disease, which, according to some authors, is an expression of a congenital defect of keratinization. It is characterized by the presence of a large number of warty papules mainly on the dorsal surfaces of the hands and feet. The papules are the color of normal skin or reddish-brown, often covered with hyperkeratotic layers.
Pathomorphology of Hopf's acrokeratosis verruciformis. Characteristic hyperkeratosis, acanthosis with thickening of the granular stand, epidermal growths are elongated and uneven. Sometimes papillomatosis is observed, which can be significant, combined with limited elevations of the epidermis in the form of a "spire", occasionally with atypical growths of the epidermis. When acrokeratosis is combined with Darier's disease, signs of the latter can be seen in the lesions. Elevations of the 'epidermis in the form of a "spire"' are typical for Hopf's acrokeratosis, but they may be absent, which makes it necessary to differentiate it from common and flat warts, in which parakeratosis and vacuolization of cells of the upper layers of the epidermis are noted.
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