Eikonol

One of the representatives of hypocholesterolemic and hypotriglyceridemic drugs, which are used for pathologies of the cardiovascular system, is Eikonal - a natural and effective lipid-lowering agent.

[1], [2]

Indications Eikonol

Eikonal accept:

As a secondary prevention of myocardial infarction (usually in combination with statins, antithrombotic drugs, β-adrenoblockers, ACE inhibitors;

With endogenous hypertriglyceridemia (the fourth type according to Fredrickson classification) - in the form of independent therapy against a background of dietary nutrition;

With hyperlipidemia of mixed etiology (third and second-b type) concomitantly with taking statins;

As a preventive and complex therapy of ischemic heart disease, prevention of sudden death in patients with IHD or hypertension.

[3],

Release form

Eikonal is made in the form of soft oval capsules with a gelatinous shell. Capsules have a yellowish-brown hue, a transparent elastic structure with a visible joint suture. Inside the capsule contains an oily, homogeneous liquid of yellow color, with an oily, pleasant aroma. With prolonged storage, the contents of the capsule may become slightly cloudy - this indicates the appearance of a small precipitate.

The blister plate contains 10 capsules of the preparation. The total packaging of cardboard contains five blister plates.

Eikonol is dispensed in pharmacies without a prescription.

[4], [5], [6]

Pharmacodynamics

The action of Eikonol is due to the rich composition of the drug - a combination of saturated and unsaturated fatty acids Omega-3, vitamin A and vitamin D.

Eikonol has antiatherosclerotic, lipid-lowering and antiplatelet properties.

The hypolipidemic property is explained by the ability to normalize the structure and composition of low and very low density lipoproteins.

Eikonol provokes a change in the properties of cell membranes and the activation of membrane receptors, which positively affects the cell-lipid interaction. At the same time, the production of triglycerides in the liver is inhibited (by inhibiting the esterification of fatty acids). The lowering of the triglyceride level is also due to the decrease in the content of free fatty acids, which are intended for their isolation. As a result, elimination of hyperlipidemia and inhibition of atherosclerotic processes are observed.

The increase in the content of high density lipoproteins is unstable and insignificant, especially compared with fibrates.

The duration of the hypolipidemic effect (after one year of treatment with the drug) is not known. There are few arguments about reducing the risk of CHD development.

The antiaggregant effect of Eikonol is due to a change in lipid composition of the erythrocyte cell membranes, a decrease in the amount of arachidonic acid in them, and an increase in the amount of eicosapentaenoic acid. These processes lead to a decrease in the production of thromboxane A² and other biconicient eicosanoids, which accelerate platelet aggregation and increase the production of thromboxane A³ and other eicosanoids, which do not have a proaggregant effect.

No significant changes in the coagulating factors were detected.

[7], [8], [9],

Pharmacokinetics

After using the Eikonol capsule, the absorption of the drug components can occur in three versions:

• delivery of fatty acids to the liver, with the inclusion of lipoproteins and redirection to the peripheral accumulation of lipids;
• replacement of phospholipids of cell membranes with phospholipids of lipoproteins (after that fatty acids become precursors of all possible eicosanoids);
• oxidation of most fatty acids for energy supply of the body.

The content of omega-3 fatty acids in plasma phospholipids coincides with the content of fatty acids in the composition of cell membranes.

Dosing and administration

Eikonal capsules are for internal use. Drink the product with water or juice (preferably - tomato). The daily amount of the drug can be taken at a time, or 2-3 times, preferably in the morning and half an hour after lunch.

If Eikonol is used for medicinal purposes, adult patients and children from 14 years of age take 8 to 12 capsules daily. In children 2-14 years old take from 4 to 6 capsules daily. The therapeutic course lasts an average of 4-8 weeks, depending on the doctor's appointment.

If Eikonal is used for prophylaxis, it is enough to take 2 to 6 capsules daily for 4 weeks. Treatment can be repeated twice a year, preferably in the autumn-spring period.

If there is a violation of the kidneys, adjust the amount of the drug is not necessary.

[17]

Use Eikonol during pregnancy

Eikonol is not recommended for use by pregnant or lactating women, as certain properties of the drug have not been adequately studied at the moment.

Contraindications

Eikonol is not prescribed or used:

• with exogenous hypertriglyceridemia (the first type according to Fredrickson);
• in the acute phase of chronic cholecystitis;
• with pathologies of the liver and bile excretory system;
• with calculous cholecystitis;
• with hemorrhages;
• during pregnancy and breastfeeding;
• at a high probability of allergy to the drug;
• with hereditary pathologies of blood coagulability.

[10], [11]

Side effects Eikonol

During the period of treatment with Eikonol, unwanted concomitant symptoms may appear:

• throwing the contents of the stomach into the esophagus, belching with a fishy taste, nausea, increased gas formation, upset of the stool;
• skin rashes;
• allergy.

[12], [13], [14], [15], [16]

Overdose

Signs of an overdose are side effects, manifested in a greater degree. In addition, with prolonged treatment of Eikonol can occur:

• drowsiness;
• weakness;
• pain in the head;
• attacks of nausea and vomiting;
• pain in the legs, associated with bone demineralization.

When these symptoms appear, the doctor will prescribe symptomatic therapy, and Eikonol in such cases is canceled.

Interactions with other drugs

• Eikonal and oral anticoagulants in combination with each other can lead to lengthening of the bleeding period.
• Eikonol with Warfarin requires periodic monitoring of prothrombin time.
• Do not combine Eikonol with fibrates (derivatives of fibroic acid).
• The action of Eikonol is enhanced by vitamins A and E, ascorbic and pantothenic acids, thiamine, pyridoxine, riboflavin, as well as magnesium-based drugs.
• The combination of Eikonol with vitamins A and D can lead to the development of vitamin intoxication.

[18], [19], [20], [21], [22], [23]

Storage conditions

Eikonol is kept in a cool dry place, beyond the children's access. The maximum permissible temperature for storage is not more than +20 ° C.

[24], [25]

Shelf life

Eikonol can be stored for up to 3 years.