Classification of polyneuropathic syndromes

I. Acute polyneuropathy mainly with motor manifestations and variable sensory and vegetative disorders.

1. Guillain-Barre syndrome (acute inflammatory demyelinating polyneuropathy).
2. Acute axonal form of Guillain-Barre syndrome.
3. Acute sensory neuropathy syndrome.
4. Diphtheria polyneuropathy.
5. Porphyria polyneuropathy.
6. Some forms of toxic polyneuropathy (thallium, trorthocresil phosphate).
7. Paraneoplastic polyneuropathy (rarely).
8. Polyneuropathy with acute pandisavtonomia.
9. "Tick-paralysis" is an ascending flaccid paralysis caused by a tick bite, a carrier of a viral, bacterial or rickettsial infection.
10. Polyneuropathy of critical states.

II. Subacute polyneuropathy with sensorimotor manifestations.

A. Symmetrical polyneuropathies.

1. Deficient conditions: alcoholism (beriberi), pellagra, insufficiency vit. B12, chronic gastrointestinal diseases.
2. Intoxication with heavy metals and organophosphorus substances.
3. Drug intoxication: isoniazid, disulphuram, vincristine, cisplatinum, diphenine, pyridoxine, amitriptyline, etc.
4. Uremic polyneuropathy.
5. Subacute inflammatory polyneuropathy.

B. Asymmetric neuropathies (multiple mononeuropathies).

1. Diabetes.
2. Nodular periarteritis and other inflammatory angiopathic neuropathies (Wegener's granulomatosis, vasculitis, etc.).
3. Cryoglobulinemia.
4. Dry Sjogren's syndrome.
5. Sarcoidosis.
6. Ischemic neuropathy in peripheral vascular diseases.
7. Lyme disease.

C. Unusual sensory neuropathies.

1. Migrating sensory neuropathy of Wartenberg.
2. Sensory perineuritis.

D. Primary damage to rootlets and membranes (polyradiculopathy).

1. Neoplastic infiltration.
2. Granulomatous and inflammatory infiltration: Lyme disease, sarcoidosis, etc.
3. Diseases of the spine: spondylitis with secondary involvement of rootlets and membranes.
4. Idiopathic polyradiculopathy.

III. Syndrome of chronic sensorimotor polyneuropathy.

A. Acquired forms.

1. Paraneplastic: carcinoma, lymphoma, myeloma, etc.
2. HVDP
3. Polyneuropathy with paraproteinemia (including POEMS syndrome)
4. Uremia (sometimes subacute).
5. Bury-Berry (usually subacute).
6. Diabetes.
7. Diseases of connective tissue.
8. Amyloidosis.
9. Leprosy.
10. Hypothyroidism.
11. Benign sensory form of the elderly.

B. Genetically deterministic forms.

1. Hereditary polyneuropathies are mainly sensory type.
   1. Dominant sensory polyneuropathy with mutations in adults.
   2. Recessive sensory neuropathy with mutations in children.
   3. Congenital insensitivity to pain.
   4. Other hereditary sensory neuropathies, including those associated with spinocerebellar degenerations, Riley-Deia syndrome and the syndrome of universal anesthesia.

C. Hereditary polyneuropathies of mixed sensorimotor type.

1. Idiopathic group.
   1. Peroneal muscular atrophy of Charcot-Marie-Toot; hereditary motor-sensory neuropathy type I and II.
   2. Hypertrophic polyneuropathy of Dejerine-Sottas (adult and child type).
   3. Polyneuropathic syndrome of Russi-Levy (Roussy-Levy).
   4. Polyneuropathy with optical atrophy, spastic paraparesis, spinocerebellar degeneration, delayed mental development.
   5. Hereditary paralysis of pressure.
2. Hereditary polyneuropathies with a known metabolic defect.
   1. Refsum is a disease.
   2. Metachromatic leukodystrophy.
   3. Globoid cell leukodystrophy (Krabbe disease).
   4. Adrenoleukodystrophy.
   5. Amyloid polyneuropathy.
   6. Porphyria polyneuropathy.
   7. Anderson-Fabry (Anderson-Fabry) disease.
   8. Abetalipoproteinemia and Tanger disease.

IV. Neuropathy associated with mitochondrial diseases.

V. Syndrome of recurrent polyneuropathy.

• A. Guillain-Barre syndrome.
• B. Porphyry.
• V. HVDP.
• D. Some forms of multiple mononeuropathy.
• D. Beri-Beri and intoxication.
• E. Refsuma disease, Tanger disease.

VI. Syndrome mononeuropathy or plexopathy.

• A. Brachial plexopathy.
• B. Brachial mononeuropathy.
• V. Kauzalgiya (CRPS type II).
• G. Lumbosacral plexopathy.
• D. Crural mononeuropathies.
• E. Migrating sensory neuropathy.
• G. Tunneling neuropathies.

POEMS syndrome (polyneuropathy, organomegaly endocrinopathy, M protein, skin changes) - syndrome polyneuropathy, organomegaly, endocroinopathy, increased content of so-called M-protein in the blood serum, pigment changes in the skin. It is observed with some forms of paraproteinemia (most often with osteosclerotic myeloma).

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