Medical expert of the article

Endocrinologist

New publications

Causes of an increase and decrease in testosterone

Alexey Kryvenko, medical expert
Last reviewed: 23.04.2024

All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.

We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.

If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.

Diseases and conditions in which the concentration of testosterone in the blood serum changes

Testosterone is elevated under the following conditions:

Uremia.
Myotonic dystrophy.
Liver failure.
Klinefelter's syndrome.
Cryptorchidism.
Primary and secondary hypogonadism.
Cullman's syndrome.
The use of barbiturates, clomiphene, estrogen, gonadotropin, oral contraceptives.
Idiopathic hirsutism.

Testosterone is lowered under the following conditions:

Men with a karyotype of XYY.
Syndrome of Stein-Leventhal.
The syndrome of feminizing testes.
Premature puberty of boys.
Virilizing luteum.
Tumors of the adrenal cortex.
Extragonadal tumors in men, arenoblastoma.
The use of androgens, dexamethasone, diethylstilbestrol, digoxin, ethanol, halothane, spironolactone, phenothiazines.
Free testosterone in the blood serum.

trusted-source [1], [2], [3], [4], [5]