Reasons for increasing and decreasing alpha2-antiplasmin
Last reviewed: 19.10.2021
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
A decrease in the activity of alpha 2 -antiplasmin is observed in severe hepatitis, cirrhosis, chronic tonsillitis, DIC syndrome, thrombolytic therapy with streptokinase. In patients with chronic course of DVS-syndrome, plasminogen is slowly activated and the content of alpha 2 -antiplasmin decreases sharply, which is associated with rapid elimination of the alpha 2- antiplasmin-plasmin complex. In patients with low alpha- 2 -AP-AP and reduced fibrin-stabilizing factor, the postoperative period may be complicated by bleeding.
An increase in the concentration of alpha 2 -antiplasmin in the blood is possible in patients with diabetes mellitus who have suffered a streptococcal infection, with malignant neoplasms, acute thrombosis, after surgical interventions.