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Reasons for increasing and decreasing alpha2-antiplasmin
Last reviewed: 19.10.2021
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A decrease in the activity of alpha 2 -antiplasmin is observed in severe hepatitis, cirrhosis, chronic tonsillitis, DIC syndrome, thrombolytic therapy with streptokinase. In patients with chronic course of DVS-syndrome, plasminogen is slowly activated and the content of alpha 2 -antiplasmin decreases sharply, which is associated with rapid elimination of the alpha 2- antiplasmin-plasmin complex. In patients with low alpha- 2 -AP-AP and reduced fibrin-stabilizing factor, the postoperative period may be complicated by bleeding.
An increase in the concentration of alpha 2 -antiplasmin in the blood is possible in patients with diabetes mellitus who have suffered a streptococcal infection, with malignant neoplasms, acute thrombosis, after surgical interventions.