Alpha 2 antiplasmin
Last reviewed: 23.04.2024
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The reference values (norm) of the alpha 2 -antiplasmin content in the blood plasma are 80-120%.
Alpha 2- antiplasmin is the main fast-acting plasmin inhibitor. It suppresses fibrinolytic and esterase activity almost instantaneously. The mechanism of its action is based on the fact that it interferes with the adsorption of plasminogen on fibrin, thus reducing the amount of plasmin formed on the surface of the clot and thereby dramatically slowing down fibrinolysis. The specific binding of alpha 2 -antiplasmin to fibrinogen requires the presence of factor XIII. Alpha 2- antiplasmin characterizes the state of the system of inhibitors of fibrinolysis.
Determination of alpha 2 -antiplasmin is used in a complex assessment of the state of the plasmin system. When evaluating the content of alpha 2 -antiplasmin, it must be taken into account that it depends on the content of plasminogen and on the amount of fibrinogen in the blood.
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