^

Health

A
A
A

Tubular dysfunction

 
, medical expert
Last reviewed: 23.04.2024
 
Fact-checked
х

All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.

We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.

If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.

Nephropathy, characterized mainly by a violation of transport processes, as a rule, with a preserved filtration function of the kidneys, tubular dysfunction.

Causes of the tubular dysfunction

Most of the tubular dysfunction is primary, genetically determined; symptoms of tubular dysfunction develop usually already in childhood. Genetically determined tubular dysfunction is caused by mutations that cause changes in the structure of membrane carrier proteins, functional insufficiency of membrane proteins, and changes in the sensitivity of tubular epithelium cells to the action of hormones.

However, in some diseases, secondary tubular dysfunction is observed.

trusted-source[1], [2], [3], [4], [5], [6], [7]

Forms

Classification of tubular dysfunction

  • Glucosuria.
  • Aminoaciduria :
    • aminoaciduria with excretion of cystine or dibasic amino acids;
    • aminoaciduria with excretion of neutral amino acids;
    • iminoglycinuria and glycinuria;
    • aminoaciduria with excretion of dicarboxylic amino acids.
  • Disorders of reabsorption of phosphates.
  • Renal tubular acidosis:
    • proximal;
    • distal.
  • Fanconi syndrome.
  • Kidney diabetes insipidus.
  • Tubular dysfunction with hypokalemia.

Tubular dysfunction is subdivided by localization - the primary involvement of the proximal or distal tubule.

In the designation of tubular dysfunction, usually a substance and / or an ion whose transport is impaired (isolated glucosuria, cystinuria) is called.

trusted-source[8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]

What do need to examine?

What tests are needed?

Who to contact?

You are reporting a typo in the following text:
Simply click the "Send typo report" button to complete the report. You can also include a comment.