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Analysis for hepatitis G: IgG antibodies to HGV in the blood
Last reviewed: 23.04.2024
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Viral hepatitis G is an infectious disease with the parenteral mechanism of infection (mainly with blood transfusions). The virus of hepatitis G (HGV) is classified as the Flaviviridae family . The genome of the virus is represented by single-stranded RNA. Currently, there are at least three genotypes and several subtypes of HGV, distributed according to their geographical origin. The virus contains a lipid membrane that serves as an obstacle to the formation of immune complexes of the antigen-antibody during the persistence of the virus in the human body. Clinical manifestations of the disease in comparison with other forms of viral hepatitis are less pronounced. Only 30-50% of those infected with viral hepatitis G have an increase in serum transaminase activity.
The main laboratory marker of viral hepatitis G is the detection of a virus RNA in the blood by the PCR method. For the retrospective diagnosis of viral hepatitis G, the detection of specific AT-class IgGs to the envelope protein E2 HGV in serum can be used.
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