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Hemolytic anemia associated with mechanical damage of erythrocytes
Last reviewed: 23.04.2024
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[Symptoms of microangiopathic hemolytic anemia
Trauma can be localized outside the vascular bed, for example, with body strikes, leg injuries (march hemoglobinuria), karate fighting; can be caused by cardiac work through a pressure gradient with aortic stenosis or a malfunctioned aortic valve prosthesis; can be localized in arterioles with severe (especially malignant) hypertension, with some malignant tumors, nodular polyarthritis; can be localized in terminal arterioles when filaments of fibrin are deposited in thrombotic thrombocytopenic purpura or disseminated with intravascular coagulation. Injury causes an additional change in the shape of red blood cells (for example, the shape of a tropical helmet, triangle), which are called schistocytes. These changes can be established in a blood smear. Schistocytes of small size determine the presence of low MCV and high RDW (later manifestation of anisocytosis).
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Treatment of microangiopathic hemolytic anemia
Treatment is directed to the main process. Sometimes as a result of hemolysis and chronic hemosiderinuria, iron deficiency anemia develops, in which the use of iron-replacement therapy is effective.