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Treatment of febrile intoxication syndrome
Last reviewed: 06.07.2025
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Treatment of febrile intoxication syndrome is aimed at detoxification and reduction of excessive temperature reaction. In case of mild intoxication and subfebrile fever, home regimen is indicated, exclusion of hot spices, fried foods, smoked foods, canned food, plenty of fluids (tea, juices, fruit drinks, mineral water, rosehip decoction, compote - up to 3 liters per day).
In case of moderate intoxication and moderate fever, bed rest is indicated, hospitalization according to individual indications in some cases (fever over 5 days, aggravated premorbid background), the same diet as in case of mild intoxication with the exclusion of refractory fats, plenty of fluids with the inclusion of diaphoretics - honey, raspberries, lingonberries, ascorbic acid. In case of poor subjective tolerance of fever - antipyretics: acetylsalicylic acid, paracetamol, metamizole sodium, cold on the forehead.
In case of severe and very severe intoxication and fever over 39.0 °C, hospitalization and strict bed rest are indicated. Mechanically and chemically gentle diet with restriction of fats and proteins, plenty of fluids, physical methods of cooling, antipyretics taking into account general and individual contraindications, detoxification by intravenous administration of solutions (polyionic solutions, 5-10% glucose solution, albumin, plasma, rheopolyglucin) in a volume of 0.5-1.5 liters per day. According to indications (hypotension, encephalopathy, acute myocardial infarction), intensive therapy is carried out in the intensive care unit.
Antimicrobial drugs are not indicated before diagnosis at home. In hospital conditions (after blood sampling for bacteriological examination) if a severe infection is suspected - according to vital indications. Broad-spectrum drugs are used parenterally.
Corticosteroids (prednisolone) as a detoxifying agent are used only for individual indications against the background of antimicrobial therapy. The dose of the drug is up to 10 mg/kg of body weight.