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Silicotic granuloma: causes, symptoms, diagnosis, treatment
Last reviewed: 20.11.2021
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Granuloma silicic is formed when the quartz, siliceous dust, sand, glass particles, gravel, bricks get through the damaged skin. Clinically, the development of trauma in place after a significant period of time of reddish-cyanotic or brown papular elements, occasionally ulcerating, is characterized clinically. A similar pattern can be observed when a talcum enters the open wound.
Pathomorphology of granuloma silicosis. The microscopic picture is characterized by diffuse inflammatory infiltration of the dermis, consisting of a large number of macrophages and multinucleated giant cells of foreign bodies. There are no signs of organization inside the granuloma. In some cases, the inflammatory reaction, on the contrary, is weak, the tuberculoid structure of the infiltrate predominates. Tuberculosis consists of epithelioid cells with an admixture of giant multinucleated cells. The diagnosis of silicic granuloma is facilitated by the detection inside the infiltrate of colorless crystalline particles of various shapes and sizes (from the visibility limit of up to 100 μm). When investigated in a polarization microscope, these particles are birefringent.
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