Diagnosis of SEN infection
It should be remembered that if a negative test results for markers of hepatitis AG viruses, excluding another infectious nature of hepatitis, the doctor can meet with liver damage with primary biliary cirrhosis, primary sclerosing cholangitis. In view of the similarity of the onset of the disease, changes in the biochemical parameters of the blood, patients with autoimmune, drug and alcoholic hepatitis often enter the infectious hospital. Finally, hepatitis can be the first manifestation of Wilson-Konovalov's disease.
Nevertheless, even with the exclusion of all listed diseases, in some cases the etiology of hepatitis remains unclear, although epidemiological data, clinical features of the disease, the nature of liver damage and biochemical changes suggest a viral etiology of the disease. As a rule, such patients are diagnosed as "unspecified viral hepatitis" (ICD-10 code is B19). It can also be referred to as viral hepatitis, neither A nor G. The "applicants" for the role of etiological agents of this hepatitis can be TTV and SEN viruses.
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Laboratory diagnosis of SEN infection
The main method for detecting TTV at the present time is PCR. Attempts have been made to create a test system for determining the IgM and IgG content of a TTV virus. It was shown that antibodies of class M appear at the beginning of the disease, circulate simultaneously with TTV DNA, and then disappear, and antibodies of class G appear. However, these methods of laboratory diagnostics are in the stage of scientific development and are not yet used in clinical practice. In addition, there are no commercial test systems for detecting SEN virus markers in body fluids.