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Ophthalmologist, oculoplastic surgeon

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Phacogenic open-angle glaucoma: causes, symptoms, diagnosis, treatment

Alexey Kryvenko, medical expert
Last reviewed: 08.07.2025

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Phacogenic open-angle glaucoma includes three different diagnoses with similar clinical symptoms. Phacolytic glaucoma, glaucoma of the lens masses, and phacogenic uveitis (FGU) develop with an intraocular inflammatory process, an abnormal lens, and increased intraocular pressure, but hypotension usually develops later. Differentiation of these three pathologies requires careful examination and understanding of the mechanisms that determine the development of each disease.

Clinical manifestations of phacogenic open-angle glaucomas

	Glaucoma of the lens masses	Phacolytic glaucoma	Phacogenic open-angle glaucoma
Mechanism	The lens substance blocks the TS	VMB of the lens blocks the TS	Immune tolerance disorder
Intraocular pressure	Increased	Increased	Decreased or increased
Gonioscopy	Open corner	Open corner	Open corner
Condition of the lens	Rupture of the lens capsule with release of lens masses	Mature or hypermature cataract	Rupture of the lens capsule; expulsion of large fragments of the lens
Treatment	Antiglaucoma treatment, glucocorticoids, surgical removal of lens masses	Antiglaucoma treatment, local glucocorticoids, cataract extraction	Antiglaucoma treatment, local glucocorticoids, removal of lens fragments

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