Overview of drugs for treatment of thrush in women and men

To date, there are many drugs to eliminate thrush. A wide range of different forms of medication with different efficacy and price allows you to choose the best option for therapy. But you can take the medicine only for medical purposes, after you have passed all the necessary tests and examination. Self-medication can cause serious consequences and translate the ailment into a chronic, recurrent form.

All pharmaceutical products are divided into 4 groups:

• Antifungal, topical action (vaginal tablets, suppositories, creams for insertion into the vagina).
• Antimicrobial, topical.
• Antifungal, general action for oral administration (tablets, capsules).
• Combined topical preparations.

Therapy is carried out in several directions simultaneously. First of all, it eliminates risk factors, taking antimycotic tablets and restoring the normal vaginal microflora.

As for local treatment, the main advantage of candles, ointments and creams is that they have a quick effect. Thrush can be eliminated within 1-6 days. Disadvantage - requires a second course, which is a guarantee of recovery. All procedures are best done before bedtime.

The most popular drugs:

• Clotrimazole (Yenamazol 100, Kanesten, Canison)
• Miconazole (Ginezol 7, Clion-D 100)
• Nystatin (Polizinaks, Terzhinan)
• Ketoconazole (Livarol, Ketoconazole, Mycosoril, Nizoral, Perhotal)
• Natamycin (Pimafucin).

[1], [2], [3], [4], [5], [6],

Fluconazole

Fluconazole is a triazole derivative with antifungal properties. It has high specificity when interacting with fungal enzymes, which are dependent on cytochrome P450.

• Well absorbed, bioavailability exceeds 90%. Eating does not affect the level of absorption. The maximum concentration in the blood plasma is reached after 1-1,5 hours after administration. Penetrates into all body fluids, is excreted by the kidneys.
• The dosage is individual for each patient. Depending on the clinical situation and treatment regimen can appoint from 50 to 400 mg per day. The duration of therapy depends on the clinical and mycotic effect.
• When pregnancy and lactation are taken only as prescribed by the doctor, when there are potentially life-threatening fungal infections. If the drug is used by patients of childbearing age, then it is recommended to use reliable contraceptives. The active substance is excreted in breast milk in high concentrations.
• There are side effects: headache, cramps, abdominal pain, vomiting, nausea. In rare cases, there are dermatological reactions: rash, skin diseases.

[7], [8], [9], [10], [11], [12], [13], [14]

Nystatin

Nystatin - an effective antifungal antibiotic, is available in the form of tablets, vaginal and rectal suppositories. Active with yeast-like fungi of the genus Candida.

• After intake of poorly absorbed from the gastrointestinal tract, with local application does not enter the systemic bloodstream. It is deduced with kalovymi masses. Eating does not affect the absorption process.
• If it is prescribed for candidiasis of internal organs, it is recommended to take 50 mg 4-8 times a day. With generalized candidiasis take 250 mg 3-4 times a day. The duration of therapy is 7-14 days with a mandatory repeat course to prevent relapse.
• The drug is contraindicated to use during pregnancy and lactation. To date, there have been no cases of overdose. If it is taken simultaneously with clotrimazole, then the activity of the second decreases.
• Side effects most often arise from the digestive system, causing nausea, diarrhea and vomiting. In rare cases, allergic reactions to skin and fever are possible.
• Contraindicated to use in pancreatitis, violations of liver function and pregnancy. Peptic ulcer disease of the duodenum and stomach and intolerance of the components are also a ban on use.

Miramistine

Miramistin is an antiseptic for external and topical application. A monohydrate is produced in the form of a solution with the active substance benzyldimethyl-myristoylamino-propylammonium chloride. Has a broad antibacterial effect and a pronounced bactericidal action against gram-positive, gram-negative, anaerobic and aerobic bacteria. The drug has an antifungal effect and is effective in yeast-like Candida fungi.

• Local application is not accompanied by absorption of active substances through mucous membranes and skin. To treat thrush, irrigation and baths are used. The procedures can be carried out both in the morning and in the evening, lasting from 5-12 days.
• To date, there are no data on cases of an overdose of Miramistin. With simultaneous use with antibiotics, there is an increase in their antifungal and antibacterial properties.
• In some cases, side effects occur, as a rule, these are local reactions - mild burning and redness, which go through 10-20 seconds, so the drug is not required to be withdrawn. In rare cases, allergic reactions occur. It is forbidden for hypersensitivity to active components.

Terjinan

Terzhinan is an antibacterial medication with antiprotozoal, anti-inflammatory and antifungal properties. Issued in the form of vaginal tablets for topical use with active ingredients: ternidazole, nystatin and neomycin sulfate. Included in the group of imidazole derivatives, as it reduces the synthesis of ergosterol, is active against anaerobic bacteria.

• The dosage is individual for each patient. Tablets are injected deep into the vagina in the supine position. The procedure is best done before bedtime. On average, the course lasts 10 days, if preventive therapy is given, then 6 days.
• Terzhinan is allowed to use from the second trimester of pregnancy. At earlier times and with breastfeeding do not use.
• Side effects are accompanied by local allergic reactions (irritation, itching, burning in the vagina). The main contraindication is intolerance of the components. It is not recommended to stop taking during menstruation.

Livarol

Liverol - a topical drug with antifungal properties. The medicine is released in the form of vaginal suppositories of yellowish or grayish color with the active substance ketoconazole. Included in the category of derivatives of imidazole-dioxolane for topical application. It is active against yeast fungi and dermatophytes.

• Since it is used intravaginally, systemic absorption is insignificant. Classical treatment scheme - one suppository before bedtime for 3-5 days. If the therapy is chronic form of candidiasis, then the drug is used for 10 days.
• Suppositories are not used in the first trimester of pregnancy and with individual intolerance of its components. For medical purposes, you can use in the second and third semesters, as well as during lactation.
• In some cases, the drug causes flushing and irritation of the vaginal mucosa. Very rarely, patients complain of hives, rashes and other allergic reactions.

Metronidazole

Metronidazole is an antifungal agent with antibacterial action. Issued in the form of tablets, suppositories, solution and gel for topical application. The active substance - metronidazole, has antimicrobial and antiprotozoal properties, is a derivative of 5-nitroimidazole. It is active against many gram-negative and gram-positive microorganisms, as well as anaerobes.

• Has a high penetrating ability, therefore accumulates in all tissues and body fluids. The therapeutic concentration lasts for 6-8 hours, about 30-60% is metabolized by hydroxylation.
• The maximum single dose is 500 mg, the duration of the course is determined individually. Depending on the nature of the fungal infection, there may be a transition from oral to intravenous form or vice versa.
• When an overdose appears such symptoms: nausea and vomiting, convulsions. Since there is no specific antidote, supportive and symptomatic therapy is used. Contraindicated in the first trimester of pregnancy, as well as breastfeeding. Side effects arise from all organs and systems, but most often it is nausea and vomiting, allergic reactions to the skin.
• It is forbidden for organic lesions of the central nervous system, for leukopenia, for hepatic or renal insufficiency, and for hypersensitivity to the components of the drug. In the second and third trimesters of pregnancy, use is only possible for medical reasons.

Fucis

Fucis is a broad-spectrum antifungal medication. The active substance - fluconazole causes the death of a fungal infection at the cellular level. It is active against Cryptococcus neoformans, Microsporum spp. And Trichophytum spp., Coccidioides immitis, Blastomyces dermatitidis, Hystoplasma capsulatum. Has a high fungicidal activity against Candida spp. And other fungal microorganisms.

• When oral administration is well absorbed in the digestive tract. Has a high bioavailability of 90%, food intake does not affect the degree of absorption. Binding to blood plasma proteins is low. The active substance penetrates well into all biological fluids. Most of it is excreted unchanged in the urine and part of it in the form of metabolites.
• For patients with invasive forms of candidiasis prescribe 400 mg of the drug on the first day of treatment and further reduce the dose to 200 mg. With oropharyngeal candidiasis, take 50-100 mg once a day. With genital lesion - 150 mg, duration of treatment 7-14 days.
• Side effects and symptoms of an overdose are accompanied by headaches and dizziness, tachycardia, arrhythmia, seizures, nausea, vomiting and epigastric pain. Contraindicated with intolerance of its components or other azole compounds that are close in structure to the active component. Do not prescribe during pregnancy and lactation.

Zalain

Zalain - antifungal suppositories of topical use, used in gynecology. The active substance is sertaconazole nitrate. Refers to benzothiophene and imidazole derivatives. The mechanism of action is based on inhibition of the synthesis of ergosteroid, which causes fungal death at the cellular level. It is active against Candida spp. And Gram-positive bacteria.

• Since the drug is intended for intravaginal administration, the active ingredient is not absorbed and does not enter the systemic circulation. The course takes seven days, every day at night you need to enter one suppository. Before using it, it is recommended to wash the external genitalia using alkaline soap.
• The period of pregnancy is forbidden, but application at thoracal feeding with corresponding medical recommendations is possible. Very rarely there are side effects, which are accompanied by itching, burning and unpleasant sensations in the vagina. Do not use with intolerance imidazole, benzotifen or other components.

Malawi

Malavit is a naturopathic agent intended for external use, that is, treatment of mucous membranes and skin. Has antipruritic, analgesic, anti-edematous and deodorizing properties. Effective fights against infectious diseases caused by anaerobic and aerobic bacteria. Can act as an independent medication, and in complex therapy, strengthening the actions of other drugs.

• The solution is needed for external use. So, for hygienic purposes, 10 ml of the drug is added to the bath with 200 liters of water. As for the dosage for the baths for thrush, the dose is selected by the doctor, focusing on the stage and form of the disease.
• Side effects occur in isolated cases, causing allergic reactions. Do not use if hypersensitivity to its components. There are no data on use during pregnancy and contraindications.

Klion d

Klion D - antibacterial, antiprotozoal and antifungal medication. The active substance is metronidazole. Issue in the form of a solution, tablets, vaginal suppositories. When intravaginal application is absorbed into the systemic circulation. It is active against many anaerobes, aerobic microorganisms, dermatophytes, gram-positive bacteria and fungi. Effectively eliminates itching and infections caused by yeast, without changing the pH and microflora of the vagina.

• Tablets are taken for 10 days for 250 mg, the solution is administered intravenously drip in 100 ml for 7 days, vaginal suppositories are used for 10 days, one per day.
• Side effects are accompanied by itching, burning and pain in the vagina. Possible nausea, changes in taste, decreased appetite and dry mouth. In rare cases, there are allergic reactions to the skin, constipation, headaches and dizziness.
• Do not use when hypersensitivity to its components, as well as blood diseases, kidney and liver failure, during pregnancy (first trimester) and breastfeeding. With extreme caution apply when there is a violation of microcirculation and diabetes mellitus.

Metrogil

Metrogil is a broad-spectrum medicine with bactericidal properties. Effective against anaerobic microorganisms, protozoa and Gram-positive bacteria. The active component - metronidazole is a derivative of nitroimidazole. Issued in the form of tablets and a solution for intravenous administration.

• When ingested, their digestive tract is well absorbed. The maximum concentration in the blood plasma is reached within 120 minutes. The substance penetrates into all biological tissues and body fluids. Binding to proteins is low - 18-20%. It is excreted by the kidneys, but a small part comes in the form of metabolites with feces.
• The medicine is taken as prescribed by the doctor. Tablets are recommended to drink during or after eating, squeezed with enough liquid. Doses are selected by the attending physician, for each patient individually. For candidiasis therapy take 200 mg per day for 3-5 days, a possible preventive course is possible.
• Side effects are most often manifested by the nervous system, causing severe headaches, dizziness, disturbed sleep and irritability. In addition, patients face stool disorders, nausea and vomiting, inflammatory diseases of the oral cavity (glossitis, stomatitis). There may be darkening of the urine, redness around the perineum, leukopenia and skin allergic reactions.
• Contraindicated with intolerance of its components and other derivatives of nitroimidazole. It is forbidden in the first trimester of pregnancy and with lactation. When an overdose appears nausea, dizziness, vomiting, headaches. There is no specific antidote.

Epigen spray

Epigen spray is an antiviral agent for topical application. The active substance - glycyrrhizic acid is active against DNA containing viral cells. It stops the replication of viruses in the early stages and prevents their penetration into the cells. Has analgesic and anti-inflammatory effect, improves tissue regeneration, which allows you to cure the disease more quickly.

• Dosage is individual and depends on the indications for the use of the drug, that is, the form and degree of candidiasis infection. Application during pregnancy and lactation is possible in absolute terms.
• Side effects are accompanied by allergic reactions. The main contraindication is hypersensitivity to the active ingredient.

Rumisol

Rumisol is a vaginal suppository used to treat vaginal candidiasis, bacterial vaginosis and mixed vaginal infection. The active substance is metronidazole.

• Before use, the suppository should be removed from its shell and inserted deep into the vagina. It is recommended to enter 1 candle at night and in the morning for 7 days. If the thrush has a recurrent nature, the course lasts 14 days.
• It is forbidden in the first trimester of pregnancy and with lactation. Hypersensitivity to the components of the drug and its derivatives, severe violations of the liver, epilepsy and porphyria are the main contraindications to use.
• Side effects are expressed as local allergic reactions and irritation of the vagina. Possible headaches and dizziness, psycho-emotional disorders, dry mouth, diarrhea, loss of appetite, nausea and vomiting.
• When an overdose appears nausea and vomiting, stomatitis, headaches, diarrhea. Symptomatic and maintenance therapy is used for treatment. If the suppository was taken orally, then gastric lavage is necessary.

Irunin

Irunin - an antifungal drug with an active ingredient itraconazole. It is available in the form of capsules for oral administration. Has a wide spectrum of action, is active against dermatophytes, yeast fungi Candida spp. And mold fungi.

• After oral intake quickly absorbed, the maximum bioavailability occurs when taken before meals. The concentration of the active substance in tissues with keratin is several times higher than the concentration in the blood plasma. Well distributed to tissues affected by a fungal infection. Therapeutic doses in the vagina persist for two days after a three-day course of treatment. It is excreted with feces and in the form of metabolites with urine.
• Dosage is selected for each patient. For optimal absorption, the capsules must be swallowed whole, immediately after ingestion. For the treatment of vulvovaginal candidiasis, take 200 mg 1-2 times a day, the duration of treatment is 1-3 days. Oral candidiasis is treated within 15 days, taking 100 mg per day. Prohibited to use during pregnancy and breastfeeding.
• The main contraindication is intolerance of the active substance and other components of the medicine. Side effects arise from all organs and systems. Most often, patients complain of headaches and dizziness, increased fatigue, neuropathy, abdominal pain, nausea and vomiting. Possible violations of the menstrual cycle, swelling, allergic and dermatological reactions.

Rumikoz

Rumikoz is a broad-spectrum medicine with antifungal properties. The active substance - itraconazole, refers to the derivatives of triazole. The component inhibits ergosterol, which acts as the main component of fungal cells. As a result of such exposure, the cells of harmful microorganisms die due to the perforation of the cell membrane. It is active against dermatophytes, yeasts and yeast-like fungi, as well as against Histoplasma spp., Aspergillus spp., Paracoccidioides brasiliensis and other species of mold fungi. Available in the form of capsules for oral use.

• After ingestion, it is well absorbed in the intestine and reaches its maximum concentration after 3-4 hours. Excretion takes place in two stages and takes 24-36 hours. About 15% is excreted by the intestine, 0.03% by kidneys in unchanged form and 35% by metabolites within a week after administration.
• Capsules should be taken after meals without chewing or grinding. The duration of treatment is individual for each patient. For the treatment of vulvovaginal candidiasis, take 200 mg twice a day, the course of treatment 1-3 days. With oral candidiasis, take 100 mg per day for 15 days.
• Side effects often arise from the digestive system, it is vomiting and nausea, stool disorders and dyspepsia. It is possible to increase the activity of hepatic enzymes and severe toxic liver damage. In addition, there may be headaches and dizziness, allergic reactions, menstrual irregularities, staining of urine in a dark color and much more.
• The drug is contraindicated during pregnancy and lactation, as well as with individual intolerance to the active components. With special care used for liver disease, chronic kidney and heart failure.

Novaring

Novaring is a contraceptive hormone drug. The agent is released in the form of a vaginal ring that contains estrogenic and progestational components. The medicine causes a delay in ovulation, a change in the uterine endometrium, and an increase in the viscosity of the cervical mucus due to which pregnancy does not occur. Perl index (coefficient of contraceptive effectiveness) is 0.765. Normalizes the menstrual cycle, reduces the severity of PMS and algodismenore, reduces the intensity of bleeding during menstruation, which prevents the risk of iron deficiency anemia.

• Ethinyl estradiol and etonogestrel included in the vaginal ring are well absorbed into the systemic bloodstream through the mucous membrane of the vagina. Maximum plasma concentration is achieved within 1 week. Active components are metabolized in the body and excreted as metabolites with bile and kidney.
• Novaring is intended for intravaginal administration. The ring can be entered alone, choosing a comfortable position or seeking help from a gynecologist. After administration, the ring should remain in the vagina for 21 days. If it was accidentally removed, it should be rinsed with hot water and immediately put back. 7 days after the removal of the previous ring, you can enter the following. During the week-long break, menstruation should begin, but the ring is set regardless of the cycle.
• As a rule, the contraceptive is well tolerated. But minor headaches and migraines, emotional lability, increased fatigue, decreased libido are possible. If the ring is positioned incorrectly, unpleasant sensations may occur during intercourse. From the side of the digestive tract, side effects cause pain in the epigastric region, nausea, vomiting, stool. In rare cases, allergic and dermatological reactions occur.
• Novargin is contraindicated in case of intolerance of active substances. Do not administer to patients with neurological diseases, thrombosis, thromboembolism, pancreatitis, or impaired liver function. It is not recommended for liver tumors, vaginal bleeding of unexplained genesis and suspicions of pregnancy. With special care appoint to patients with diabetes mellitus, obesity, ulcer, Crohn's disease, heart valve diseases.
• When high doses are used, it causes nausea and vomiting, and possible bleeding from the vagina. There is no specific antidote, therefore, when developing the symptoms described above, it is necessary to seek medical help and conduct symptomatic therapy.

Treatment of thrush with thrino

Trichopol is a medicine used in the treatment of many diseases. It is active against certain bacteria that can affect the genitals, causing infectious and inflammatory diseases. The composition of tablets includes metronidazole, which is prescribed for trichomoniasis, bacterial vaginosis and other inflammatory and infectious diseases in the urinary tract, genitals and kidneys.

The instructions do not show evidence of activity against yeast. Moreover, metronidazole does not have bactericidal action against viruses and fungi. That is, the thrush is not sensitive to the trichopole. In addition, inappropriate use of medication can cause exacerbation of candidiasis and dramatically decrease the protective properties of the immune system.

But sometimes this medication is still included in the medical complex. This is due to the fact that often candidiasis is accompanied by other diseases, for example, bacterial vaginosis or trichomoniasis. In this case, combined therapy with antifungal agents and trichopolis will help to eliminate thrush and accompanying ailments.

Treating thrush ASD

There is a method of therapy of candidiasis with ASD Fraction. The medication was developed by A.V. Dorogovym had to become a real breakthrough in medicine. It was created to protect the human body and animals from radiation and to strengthen the immune system. It is used to treat almost all diseases, but before using it is better to consult a qualified doctor.

So, when thrush is recommended to use 1% solution of ASD, it is used for irrigation and baths, and taken inside. To use better with water, the course lasts 3-5 days, during which you need to take 2-5 ml of the drug. Douching will also be useful, for this it is necessary to take 30-60 drops of ASD per 100 ml of water. Only the boiled chilled water is suitable for dilution of the drug, both for internal and external use. Accept ASD on an empty stomach, 30 minutes before meals or 2 hours after it.

The drug is issued in a glass bottle, a rubber stoppered stopper, which is covered with a cap made of aluminum. The capacity of the vials is 50, 100 and 200 ml. Does not cause side effects and has no contraindications to use. But during therapy it is necessary to refrain from drinking alcohol, as this can cause deterioration of well-being. To date, the medication has not received official approval in the list of traditional medicine medicines. That is why many doctors are skeptical about its use and possible therapeutic properties.