New treatments for Alzheimer's disease

Science and medicine do not stand still, therefore new methods and directions in the treatment of neurodegenerative pathologies are constantly emerging.

Consider the new in the treatment of Alzheimer's:

• The drug J147 - affects the toxins that destroy neural connections in the brain and lead to the development of dementia. The drug is still at the stage of active testing, but there are already positive results. J147 improves cognitive abilities and metabolic processes, reduces the level of fatty acids in the brain.
• This development is based on genetic engineering and involves the delivery of the gene for the growth of nerves to brain neurons. The NGF gene stimulates protein synthesis, which supports the viability of neurons, and also stimulates their development and activity. To deliver the gene to the destination, a modified virus is used, which does not have a negative effect on the body. This method passes the final phase of the test.
• Another development is the transformation of connective tissue cells - fibroblasts, into neurons of the brain. For the transformation of neurons into healthy patients, the patient is given two drugs whose interaction is ensured by chemical reactions.
• To combat beta-amyloid plaques, a nano medicine was developed in the brain. The action of the drug is aimed at the destruction of compounds that disrupt communication between neurons and contribute to their death. Also, nanoparticles of polymer and gold were developed which, after ingestion, combine with beta-amyloid plaques and stop their growth.
• A computer system for choosing an effective drug. The essence of this development is that Alzheimer's disease has a genetic origin. Knowing which genes are damaged, and how certain drugs affect them, you can form the optimal drug.

All of the above methods are at the stage of development or testing, but there is already information about their positive effect.

Treatment of Alzheimer's with stem cells

Since the discovery, stem cells have turned the notion of scientists about the human body and caused a breakthrough in the field of many studies. They have proven themselves in neurodegenerative pathologies as a substitute therapy. That is, the method of treating Alzheimer's disease with stem cells is to replace the altered tissues with healthy ones.

Cellular therapy has the following properties:

• Activates regeneration processes.
• Promotes the appearance of new blood vessels.
• Restores nerve cells and lost functions of the brain.
• Eliminates neurological symptoms.
• Improves memory status.
• Increases cognitive abilities.
• Promotes the restoration of speech.
• Stabilizes the emotional background.
• Increases muscle strength and mobility.

The procedure for stem cell therapy is quite simple. With the help of liposuction, the material is collected from abdominal fat. To activate the cells, they are subjected to photodetection of the color spectrum of the monochromatic frequency and are returned in 2-3 hours as an injection.

This method of treatment does not violate the moral aspects, because the treatment is carried out by the patient's stem cells, rather than animals or embryos. In addition to dementia, cell therapy has proven itself in autism, Parkinson's disease, stroke, cardiomyopathy.

Fenamates in the treatment of Alzheimer's disease

Drugs with an active component of N-phenylanthranilic acid are fenamates. The active substance is multicomponent, since its composition includes mefenamic, meclofenam and etafenamic acid. Of particular note is mefenamic acid.

Mefenamic acid is a non-steroidal anti-inflammatory drug. Has a peripheral, central, analgesic and antipyretic effect. The therapeutic effect of Alzheimer's disease is associated with the anti-inflammatory properties of the drug, since inflammatory damage to the brain tissue is important in the pathogenesis of this disorder.

• The main clinical application: the reduction of pain in rheumatic diseases. The drug is quickly absorbed and transformed into two metabolites, which maintain a therapeutic concentration in the blood plasma for 1-8 hours. About 50% of the drug is excreted in the urine in the form of metabolites, the rest with feces in the form of an unconjugated 3-carbon metabolite. The active ingredient easily penetrates the placental barrier, can be found in milk during lactation and in bile.
• Adverse reactions: irritation of the gastrointestinal tract, dyspeptic disorders, skin allergic reactions, hemolytic anemia, bronchospasm, increased urea levels in the blood.
• Contraindications: gastrointestinal diseases, anticoagulants, pregnancy and lactation.
• Interaction with other drugs: binds to plasma proteins, exerting a potentiating effect on the activity of anticoagulants from the group of coumarins. With special care, the medicine should be taken with Warfarin.

Mefenamic acid is available in capsules of 250 and 500 mg, and there is also a 10 mg / ml suspension used in pediatric practice.

[1], [2], [3], [4]

New drugs for Alzheimer's disease

Alzheimer's disease is the most common form of dementia. But despite this, today there is still no therapeutic method or medicine that would stop the pathological process. Because of this, new drugs for the treatment of neurodegenerative pathology are constantly being developed.

Consider the most promising developments:

• 1. Vaccine CAD106

Its action is directed not at the prevention of the disease, but at the destruction of progressive pathology. The vaccine contains the active components, which after the introduction into the body activate the immune system to produce antibodies to the morphological substrate - beta amyloid. Due to this, the disease slows down development.

• 2. Preparation MDA7

Development for the elimination of neuropathic pain syndrome. But during the research, it was found that the drug slows the progression of dementia. The mechanism of action of MDA7 is based on the anti-inflammatory activity in the central nervous system and the effect on cannabinoid receptors in the brain. The conducted experiments established that the drug promotes the restoration of cognitive processes, synoptic plasticity and memory.

• 3. Preparation MK-8931

Inhibits the β-secretase enzyme that cleaves protein compounds. It blocks biochemical processes - amyloid cascade, reduces the concentration of β-amyloid in the cerebrospinal fluid. According to the studies, the daily intake of the drug does not just slow down Alzheimer's dementia, but stops it. The drug is still being tested on patients with early forms of the disease.

• 4. Antidiabetic drugs

1. Rosiglitazone is a medicine prescribed for type 2 diabetes. But the scientists proved that the medicine improves memory, cognitive functions and the ability to learn.
2. Insulin khimmer - recombinant insulin and another potential drug for dementia. Increases the activity of enzymes from the group of mitogen-activated protein kinases, which are responsible for synaptic signal transmission between neurons of the brain. Increases cognitive abilities, improves memory.

• 5. Medicinal plaster Exelon

This drug is a percutaneous form of rivastigmine. The adhesive is pasted for 24 hours. During this time interval, an active component enters the bloodstream, which fights degenerative processes. The peculiarity of this medication is that the patch should be glued daily to a new area of the body, which should not come into contact with clothing.