Medical expert of the article

Surgeon, oncosurgeon

New publications

New non-invasive (bioprognostic) tests FibroActiTest, Fibromax

Alexey Kryvenko, medical expert
Last reviewed: 07.07.2025

All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.

We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.

If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.

In January 2007, the French Ministry of Health recognized FibroTest as a real alternative to liver biopsy. This served as a reason for the simultaneous introduction of these tests in a number of countries.

FibroTest displays the stages of fibrosis (T0, P1, P2, P3, P4) and the degree of necroinflammatory process (A0, A1, A2, A3) according to the internationally accepted METAVIR system, providing easy and universal interpretation of the results. These tests allow to obtain an accurate quantitative and qualitative assessment of fibrosis, steatosis and necroinflammatory changes in the liver at all stages, regardless of localization, which eliminates the possibility of error in local examination of the material, obtaining! O method of puncture biopsy.

Bioprognostic tests:

Fibro Acti Test is a combination of FibroTest and ActiTest (FibroTest is used to diagnose liver fibrosis, ActiTest is used to assess viral necroinflammatory activity);
FibroMax is a combination of five non-invasive tests: FibroTest, ActiTest, SteatoTest, NashTest, AshTest [SteatoTest diagnoses liver steatosis mainly due to abnormal ALT and GGT levels; AshTest diagnoses severe alcoholic steatohepatitis (ASH); NashTest diagnoses non-alcoholic steatohepatitis (NASH) in patients with excess body weight, insulin resistance, diabetes mellitus or hyperlipidemia.

FibroTest and FibroMax use mathematical formulas that independently check each parameter to obtain the test result. Each of these parameters individually serves as an indicator of hepatitis.

The algorithm also includes variables of age, weight, height and gender. This allows FibroTest and FibroMax to make a diagnosis with greater accuracy.

A set of biochemical indicators included in the Fibrotest and FibroMax tests

B/h, indicator	FibroTest	FibroMax
A-2-macroglobulin	+	+
Haptoglobin	+	+
Apolipoirotin A1	+	+
GGT	+	+
Total bilirubin	+	+
AJTT	+	+
ACT	-	+
Fasting blood glucose	-	+
Triglycerides	-	+
Total cholesterol	-	+

Fibrosis stage assessment using FibroTest, expressed according to generally accepted international systems

FibroTest	Assessment of fibrosis stages
FibroTest	METAVIR	Knodell	Ishak
0.75-1.00	F4	F4	F6
0.73-0.74	F3-F4	F3-F4	F5
0.59-0.72	F3	F3	F4
0.49-0.58	F2	F1-F3	F3
0.32-0.48	F1-F2	F1-F3	F2-F3
0.28-0.31	F1	F1	F2
0.22-0.27	F0-F1	F0-F1	F1
0.00-0.21	F0	F0	F0

Thus, FibroTest is an alternative to liver biopsy in patients suffering from chronic hepatitis B and C, alcoholic and non-alcoholic liver disease. Diagnostic value is confirmed for both transitional and extreme stages.