Human papillomavirus is a rather insidious form of a living organism that does not imagine life outside the donor. But, even hitting the human body, a viral infection can behave differently depending on its condition.
Any type of HPV causes the appearance of various tumors (outgrowths) on the skin and mucous membranes: warts, pointed and flat condylomas, papillomas, but not all types of the virus are capable of provoking progressive tissue neoplasia (cancer). HPV type 45 refers to a variety of the virus with oncogenic properties.
Nevertheless, this type of human papillomavirus does not always lead to the development of cancer. It is worth saying that in most cases, papillomavirus infection occurs in a latent form, i.e. There are no symptoms of pathology. To detect a mutation of cells under the influence of the virus is possible only with the help of laboratory research of tissues.
Different types of the virus cause the appearance of external symptoms in different parts of the body. With type 45 HPV, neoplasms can be found on the skin and mucous in the area of the anus and genitals, as well as on the covers of internal genital organs in women. With the latent form of the virus pathology of type 45, the presence of the virus can be found in the cervical and vaginal membranes, although no external changes are noted.
Under the influence of provoking factors, the disease can go into a subclinical form, when only certain undefined symptoms of the pathology appear. Patients can complain of unpleasant sensations and itching in the genital area, experience discomfort during sex and urination, and find incomprehensible growths in the genital area and anus. Later similar neoplasms in the form of pointed or flat (especially dangerous) warts on the inner surface of the vagina, cervix, large intestine can be found. Histological and cytological studies show the presence of hyperkeratosis (tissue densification), in some cases even virus DNA is detected.
All this time the virus is in human cells, not interacting with their DNA, but only causing increased proliferation of limited areas. But if the immune system fails, the parasite molecules build their DNA into the chromosomal set of the carrier cell. There comes the third stage of the development of pathology - the clinical (integrated form of the existence of the virus).
At this stage, it is possible to observe a change in the structure of cells - koylocytosis, which is a sign that dysplasia of the vaginal or cervical tissues is caused by the human papillomavirus. So far, histological examinations and colposcopy have not shown the presence of mag- nylated cells, but there is a noticeable proliferation of tissues on the genitals.
In 4 stages of pathology, special laboratory studies and colposcopy will show the presence of mutated structures, and directly of cancer cells, which, when detached from the locus, can spread with the lymph flow throughout the body (invasive cancer).
Now other symptoms are added to the already existing symptoms, indicating severe pathological processes in the body: weakness, dizziness, deterioration of the skin, spotting from the genital organs, soreness in the lower abdomen in women. Similar symptoms can be observed at the 3 stages of the development of a viral infection, and it is possible to determine dysplasia or cancer only by histological studies, colposcopy and biopsy (the latter is considered the most reliable method of diagnosing cancer).
HPV type 45 in women
Because HPV infection of type 45 occurs both sexually and by contact, "catch" it can and women, and men, and even children. If you believe different sources, the incidence of human papillomavirus virus is from 60 to 90% of the population, and here sex plays a decisive role.
Nevertheless, we have already mentioned that certain conditions are necessary for the transition of virus carrying into cancer: reduced immunity, susceptibility to stress, the presence of inflammatory pathologies (most often gynecological and venereal), hormonal failures. Having studied the list of disease-provoking factors, it is easy to understand that women are more susceptible not so much to HPV infection (here partners are on equal terms) as to its transition to an integrated form with development of malignant processes, in particular cervical cancer and mucous vaginas.
In most cases, the viral infection lingers for a long time in the body affected by gynecological pathologies of an inflammatory nature (vulvovaginitis, cervicitis, atypical type of cervical erosion, or pseudo-erosion). Often the virus is adjacent to sexual infections (chlamydia, genital herpes, gonorrhea, etc.).
HPV type 45 in women can be manifested by such a symptom complex:
- sensation of itching or burning in the genital area without secretions, characteristic of candidiasis (fungal infection),
- the appearance of abundant translucent secretions without an odor, sometimes with blood veins,
- unpleasant, often painful sensations when urinating,
- discomfort and pain during intercourse,
- proliferation of internal genital tissues of inflammatory nature (condylomatosis),
- the appearance of spiky kandil or flat painful rashes of reddish or white color on the inner and outer genitals, in the perineum, on the mucosa of the large intestine,
- bleeding when examined by a gynecologist at later stages due to a disruption in the structure of the epithelium and the rupture of sensitive tissues during mechanical exposure to them.
By the way, the condylomas themselves are not a dangerous symptom requiring urgent treatment. They bring more discomfort than harm. However, this is a signal symptom that can not be ignored in any way.
The most dangerous symptom of HPV is dysplasia of genital tissues, because it is considered a precancerous condition. The virus can wait for decades for a suitable moment to manifest its most insidious features, and neoplasia is a suitable medium for this, it is only immunity to give the slack.
HPV type 45 during pregnancy develops as well as in the usual state. That's only hormonal changes in the body during this period can be an impetus to the pathogenetic development of the human papilloma virus, which is fraught with cancer of the cervix.
The virus-carrying and its consequences do not affect the ability to have a child, either in the generic process, or in the fetal development of the fetus and its health. The thing is that the virus does not affect the reproductive function of a person and can not pass through the placental barrier, affecting the baby's tissues, even if a woman is diagnosed with dysplasia or cervical cancer.
Most often, infection with HPV type 45 virus does not lead to pregnancy disruption and various complications. As for newborns, only single cases of the birth of babies with papillomatosis of the larynx were recorded, and if the mothers diagnosed extensive papillomatous rashes on the genitals (the contact route of transmission of the infection).
Risk factors for the transition of HPV into a serious pathology are age over 35 years, the presence of sexually transmitted infections, cervical, ovarian and vaginal pathologies, immunodeficiency states.
HPV type 45 in men
Men can get infection with the HPV type 45 virus on a par with women, for example, with sexual contact. And since many representatives of the male population are polygamous and do not care much about their health, the probability of contracting the virus is even greater, as is the risk of subsequently infecting their regular sexual partner (girlfriend, bride, wife).
Men are less susceptible to stress factors, and hormonal imbalance is rarely diagnosed, so the chance of earning a serious pathology against HPV is somewhat lower in women than in women. However, even the men are not insured against the reduction of immunity against the background of various health disorders and poor heredity, and their general interest in smoking and drinking alcohol equates the chances of both sexes to a complication in the form of cancer.
HPV type 45 is especially dangerous in terms of development of oncological pathologies, and one should not think that cancer threatens only women. Men also have a certain risk of earning penile cancer with uncontrolled proliferation of tissues in some of its areas, although it is lower than in women (medium degree of oncogenicity). Fortunately, it is possible to detect pathology in men much earlier than in women whose main sexual organs are hidden deep inside.
Symptoms of developing papillomovirus infection in men can be considered:
- genital discomfort (itching, some soreness),
- the appearance of discharge from the penis, not associated with ejaculation,
- pain during sexual contact and during urination,
- condylomatous eruptions in the genital area (usually on the bridle, head or foreskin) and the perineum, as well as on the mucosa of the anus and the large intestine.
Grayish or pink growths on the penis easily injured, hurt and begin to bleed. Sometimes they merge into groups, creating additional discomfort. Against the background of reduced immunity, the epidermal tissues of the organ are growing, in which cancer cells can eventually be detected (most commonly squamous cell carcinoma is diagnosed).