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Disaccharidase deficiency enteropathies: diagnosis
Alexey Portnov, medical expert
Last reviewed: 23.04.2024
Last reviewed: 23.04.2024
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Diagnostic criteria for disaccharide-deficient enteropathy
- The history of intolerance to disaccharides (usually milk, sugar) and the decrease or disappearance of symptoms of enteropathy after the exclusion of these disaccharides and products containing them from the diet.
- Typical results of coprological analysis: acid reaction of stool, presence of gas bubbles (fermentation dyspepsia), undigested starch, cellulose, lactic acid.
- The results of the loading test with disaccharides (lactose, sucrose) indicate the absence of an increase in the level of glucose in the blood after ingestion of lactose (with lactase deficiency) or sucrose (with invertase deficiency) and an increase in the level of glycemia after taking monosaccharides (glucose, galactose, fructose).
- A positive hydrogen test is an increase in the hydrogen concentration in the exhaled air due to bacterial cleavage of disaccharides in the large intestine.
- A sharp decrease in activity or a complete absence of disaccharidases in biopsies of the small intestinal mucosa.
- Acceleration of intestinal peristalsis and passage of its contents after taking barium sulfate and 50 g of a certain disaccharide (lactose, sucrose).
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12]