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Disaccharidase-deficiency enteropathies - Diagnosis
Alexey Kryvenko, medical expert
Last reviewed: 06.07.2025
Last reviewed: 06.07.2025
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Diagnostic criteria for disaccharide deficiency enteropathies
- History of intolerance to disaccharides (usually milk, sugar) and reduction or disappearance of enteropathy symptoms after elimination of these disaccharides and products containing them from the diet.
- Characteristic results of coprological analysis: acidic reaction of feces, presence of gas bubbles (fermentative dyspepsia), undigested starch, fiber, lactic acid.
- The results of a loading test with disaccharides (lactose, sucrose) indicate the absence of an increase in blood glucose levels after ingestion of lactose (with lactase deficiency) or sucrose (with invertase deficiency) and an increase in glycemia levels after ingestion of monosaccharides (glucose, galactose, fructose).
- A positive hydrogen test is an increase in the concentration of hydrogen in exhaled air due to bacterial breakdown of disaccharides in the colon.
- A sharp decrease in activity or complete absence of disaccharidases in biopsies of the small intestinal mucosa.
- Acceleration of intestinal peristalsis and passage of its contents after taking barium sulfate and 50 g of a certain disaccharide (lactose, sucrose).
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12]