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Diagnosis of toxoplasmosis
Last reviewed: 06.07.2025
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The diagnosis of toxoplasmosis is established on the basis of a comprehensive examination of the patient with mandatory examination of the fundus, ECG, EEG, CT, skull radiography, examination of the affected muscles, as well as the use of special research methods. Of the clinical symptoms, prolonged subfebrile temperature, lymphadenopathy, enlarged liver and spleen, eye damage and detection of calcifications in the brain are of diagnostic significance.
Of the laboratory methods, PCR and ELISA are of decisive importance. To detect specific antibodies, RSK, RIF, RPGA, etc. are also used. In case of pregnancy pathology, examination of the woman is of great importance for diagnosis. The placenta, amniotic fluid, and membranes are examined for toxoplasma DNA.
Differential diagnostics
Acquired toxoplasmosis should be differentiated from lymphogranulomatosis, tuberculosis, rheumatism, infectious mononucleosis, benign lymphoreticulosis (felinosis), herpes infection, etc.
Congenital toxoplasmosis is differentiated from rubella, cytomegalovirus, listeriosis, sepsis, syphilis, intracranial trauma, etc.
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