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Cronkhite syndrome - Canada
Last reviewed: 07.07.2025
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[ Symptoms of Cronkhite Syndrome - Canada
This syndrome is a complex of congenital anomalies: generalized polyposis of the gastrointestinal tract (including the duodenum and stomach), nail atrophy, alopecia, skin hyperpigmentation, sometimes in combination with exudative enteropathy, malabsorption syndrome, hypocalcemia, potassium and magnesium. It is known that the main source of protein (albumin) loss in this syndrome is the affected stomach, protein is lost due to increased production of gastric mucus and multiple superficial necrosis of the polyps. Cystic dilation of the glands in the polyps is possible with this syndrome. There are also some other rare forms of hereditary and non-hereditary widespread polyposis of the digestive tract, the nosological independence of which has not yet been sufficiently established. In any case, in patients with polyposis of the stomach and duodenum or colon, the entire gastrointestinal tract should be examined (targeted X-ray examination, fibroendoscopy) in order not to miss one of the forms of widespread polyposis of the entire digestive tract. Patients with multiple polyposis of the duodenum (and the entire digestive tract) in cases where removal of polyps is not indicated or impossible should be under the dispensary observation of an oncologist.
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Cronkhite Syndrome Treatment - Canada
Treatment tactics are determined by the prevalence of polyposis, the size of the polyps, and the presence or absence of complications. Large polyps are subject to removal. The possibility of providing medical care to patients has expanded significantly with the introduction of endoscopic polypectomy, which is carried out in various ways - using electrocoagulation, laser radiation, a special loop for removing polyps, biopsy forceps, etc. The occurrence of complications - acute gastrointestinal bleeding, intestinal obstruction - is an indication for emergency surgery. Malignancy of polyps also requires surgical treatment.