Classification of polyneuropathic syndromes

I. Acute polyneuropathy mainly with motor manifestations and variable sensory and autonomic disorders.

1. Guillain-Barré syndrome (acute inflammatory demyelinating polyneuropathy).
2. Acute axonal form of Guillain-Barré syndrome.
3. Acute sensory neuropathy syndrome.
4. Diphtheritic polyneuropathy.
5. Porphyritic polyneuropathy.
6. Some forms of toxic polyneuropathy (thallium, triorthocresyl phosphate).
7. Paraneoplastic polyneuropathy (rare).
8. Polyneuropathy with acute pandysautonomia.
9. "Tick paralysis" is an ascending flaccid paralysis caused by the bite of a tick that carries a viral, bacterial or rickettsial infection.
10. Critical care polyneuropathy.

II. Subacute polyneuropathy with sensorimotor manifestations.

A. Symmetrical polyneuropathies.

1. Deficiency states: alcoholism (beriberi), pellagra, vitamin B12 deficiency, chronic gastrointestinal diseases.
2. Intoxication with heavy metals and organophosphorus substances.
3. Drug intoxication: isoniazid, disulfuram, vincristine, cisplatin, diphenin, pyridoxine, amitriptyline, etc.
4. Uremic polyneuropathy.
5. Subacute inflammatory polyneuropathy.

B. Asymmetric neuropathies (multiple mononeuropathies).

1. Diabetes.
2. Nodular periarteritis and other inflammatory angiopathic neuropathies (Wegener's granulomatosis, vasculitis, etc.).
3. Cryoglobulinemia.
4. Dry Sjogren's syndrome.
5. Sarcoidosis.
6. Ischemic neuropathy in peripheral vascular diseases.
7. Lyme disease.

C. Unusual sensory neuropathies.

1. Wartenberg's migratory sensory neuropathy.
2. Sensory perineuritis.

D. Predominant damage to the roots and membranes (polyradiculopathy).

1. Neoplastic infiltration.
2. Granulomatous and inflammatory infiltration: Lyme disease, sarcoidosis, etc.
3. Diseases of the spine: spondylitis with secondary involvement of the roots and membranes.
4. Idiopathic polyradiculopathy.

III. Chronic sensorimotor polyneuropathy syndrome.

A. Acquired forms.

1. Paraneplastic: carcinoma, lymphoma, myeloma, etc.
2. HFDP
3. Polyneuropathies in paraproteinemia (including POEMS syndrome)
4. Uremia (sometimes subacute).
5. Beriberi (usually subacute).
6. Diabetes.
7. Diseases of connective tissue.
8. Amyloidosis.
9. Leprosy.
10. Hypothyroidism.
11. Benign sensory form of the elderly.

B. Genetically determined forms.

1. Hereditary polyneuropathies, predominantly sensory type.
   1. Dominant sensory polyneuropathy with mutilations in adults.
   2. Recessive sensory neuropathy with mutilations in children.
   3. Congenital insensitivity to pain.
   4. Other hereditary sensory neuropathies, including those associated with spinocerebellar degenerations, Riley-Day syndrome, and universal anesthesia syndrome.

C. Hereditary polyneuropathies of mixed sensorimotor type.

1. Idiopathic group.
   1. Peroneal muscular atrophy Charcot-Marie-Tooth; hereditary motor and sensory neuropathy types I and II.
   2. Hypertrophic polyneuropathy of Dejerine-Sottas (Dejerine-Sottas) of adult and childhood type.
   3. Polyneuropathic Roussy-Levy syndrome.
   4. Polyneuropathy with optic atrophy, spastic paraparesis, spinocerebellar degeneration, mental retardation.
   5. Hereditary paralysis from pressure.
2. Hereditary polyneuropathies with a known metabolic defect.
   1. Refsum disease.
   2. Metachromatic leukodystrophy.
   3. Globoid cell leukodystrophy (Krabbe disease).
   4. Adrenoleukodystrophy.
   5. Amyloid polyneuropathy.
   6. Porphyritic polyneuropathy.
   7. Anderson-Fabry disease.
   8. Abetalipoproteinemia and Tanger disease.

IV. Neuropathies associated with mitochondrial diseases.

V. Relapsing polyneuropathy syndrome.

• A. Guillain-Barré syndrome.
• B. Porfiry.
• V. KhVDP.
• G. Some forms of multiple mononeuropathy.
• D. Beriberi and intoxication.
• E. Refsum disease, Tanger disease.

VI. Mononeuropathy or plexopathy syndrome.

• A. Brachial plexopathy.
• B. Brachial mononeuropathies.
• B. Causalgia (CRPS type II).
• G. Lumbosacral plexopathy.
• D. Crural mononeropathies.
• E. Migrating sensory neuropathy.
• J. Tunnel neuropathies.

POEMS syndrome (polyneuropathy, organomegaly endocrinopathy, M protein, skin changes) - a syndrome of polyneuropathy, organomegaly, endocroinopathy, increased content of the so-called M-protein in the blood serum, pigment changes in the skin. It is observed in some forms of paraproteinemia (most often in osteosclerotic myeloma).

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