Medical expert of the article

Rheumatologist, immunologist

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The causes of increase and decrease in T-lymphocytes-suppressors (CD8)

Alexey Portnov, medical expert
Last reviewed: 19.10.2021

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Diseases and conditions that lead to a change in the number of CD8-lymphocytes in the blood

Increase in the

Autoimmune diseases
Systemic lupus erythematosus
Sjogren's syndrome, Felty
Rheumatoid arthritis
Systemic sclerosis, collagenoses
Dermatomyositis, polymyositis
Cirrhosis of the liver, hepatitis
Waldenström's disease
Acquired hemolytic anemia, thrombocytopenia
Mixed connective tissue diseases
Activation of antigraft implantation immunity
Primary immunodeficiency states

Decrease in the indicator

Acquired secondary immunodeficiency states:
- bacterial, viral, protozoal infections with protracted and chronic course of tuberculosis, leprosy, HIV infection, malignant neoplasms
Heavy burns, injuries, stress
Aging
Treatment with cytostatics and immunosuppressants
Ionizing radiation (in acute period)
Enhancement of suppressor activity of cellular immunity