T-lymphocytes-suppressors (CD8) in the blood
Last reviewed: 18.10.2021
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Normally, the relative amount of T-lymphocytes-suppressors in the blood in adults is 17-37%, the absolute amount is -0.3-0.7 × 10 9 / l.
T-lymphocytes-suppressors inhibit the immune response of the body, they inhibit the production of antibodies (of various classes) due to delayed proliferation and differentiation of B-lymphocytes, as well as the development of delayed-type hypersensitivity. With a normal immune response to ingestion of a foreign antigen, the maximum activation of T suppressors is observed after 3-4 weeks.
An increase in the number of CD8-lymphocytes in the blood indicates a lack of immunity, a decrease - about the hyperactivity of the immune system. The ratio of helper and suppressor in the peripheral blood - the CD4 / CD8 index - is of major importance in assessing the state of the immune system. Reduction of the function of T-suppressors leads to the predominance of the stimulating effect of T-helpers, including those B-lymphocytes that produce "normal" autoantibodies. At the same time, their quantity can reach a critical level, which can cause damage to the body's own tissues. This mechanism of damage is characteristic for the development of rheumatoid arthritis and systemic lupus erythematosus.